Retraction Note: Chemopreventive Potential of Resveratrol in Mouse Skin Tumors Through Regulation of Mitochondrial and PI3K/AKT Signaling Pathways

The Original Article was published on 13 September 2008

Retraction Note: Pharmaceutical Research volume 26, pages 211–217(2009)

https://doi.org/10.1007/s11095-008-9723

The Editor-in-Chief has retracted this article [1] due to concerns about the reliability of the figures in this article. Specifically:

  • For Fig. 3A, the beta-actin band appears to be identical to figures from multiple other journals [2, 3, 4, 5, 6]

  • For Fig. 3C, an identical beta-actin band appears in Fig. 1B of [2] despite different conditions

  • For Fig. 3D, The first two and last two lanes of the beta-actin band appear to be identical

  • For Fig. 3D, the Cytochrome C blot appears to have be a duplication of the Apaf 1 band in Fig. 5B from [7]. Lanes III and IV seem to have been rotated and vertically stretched.

  • For Fig. 4C, the beta-actin band appears remarkably similar to Figs. 1 and 2 in [3]

  • For Fig. 5B, lanes I to V of the AKT blot appear to have been duplicated from lanes A to E in Fig. 2B of [3]. Lanes III and IV seem to have been rotated and vertically stretched.

Given these concerns, the Editor-in-Chief therefore no longer has confidence in the overall study presented in this article.

Authors Jasmine George and Yogeshwer Shukla do not agree with this retraction. Preeti Roy, Neetu Kalra, and Sahdeo Prasad have not responded to notices about this retraction.

  1. 1.

    Roy, P., Kalra, N., Prasad, S. et al. Chemopreventive Potential of Resveratrol in Mouse Skin Tumors Through Regulation of Mitochondrial and PI3K/AKT Signaling Pathways. Pharm Res 26, 211–217 (2009). https://doi.org/10.1007/s11095-008-9723-z

  2. 2.

    Arora, A., Siddiqui, I. A., & Shukla, Y. (2004). Modulation of p53 in 7, 12-dimethylbenz [a] anthracene–induced skin tumors by diallyl sulfide in Swiss albino mice. Molecular Cancer Therapeutics, 3(11), 1459–1466.

  3. 3.

    Arora, A., Kalra, N., & Shukla, Y. (2006). Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin. Cancer letters, 242(1), 28–36.

  4. 4.

    Shukla, Y., Prasad, S., Tripathi, C., Singh, M., George, J., & Kalra, N. (2007). In vitro and in vivo modulation of testosterone mediated alterations in apoptosis related proteins by [6]-gingerol. Molecular nutrition & food research,

    51(12), 1492–1502.

  5. 5.

    Kalra, N., Seth, K., Prasad, S., Singh, M., Pant, A. B., & Shukla, Y. (2007). Theaflavins induced apoptosis of LNCaP cells is mediated through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways. Life sciences, 80(23), 2137–2146.

  6. 6.

    Prasad, S., Kalra, N., & Shukla, Y. (2007). Induction of apoptosis by lupeol and mango extract in mouse prostate and LNCaP cells. Nutrition and cancer,

    60(1), 120–130.

  7. 7.

    Kalra, N., Roy, P., Prasad, S., & Shukla, Y. (2008). Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis. Life sciences, 82(7–8), 348–358.

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Correspondence to Yogeshwer Shukla.

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The online version of the original article can be found at https://doi.org/10.1007/s11095-008-9723

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Roy, P., Kalra, N., Prasad, S. et al. Retraction Note: Chemopreventive Potential of Resveratrol in Mouse Skin Tumors Through Regulation of Mitochondrial and PI3K/AKT Signaling Pathways. Pharm Res 38, 375 (2021). https://doi.org/10.1007/s11095-020-02973-y

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