Linear Delivery of Verapamil via Nanofibrous Sheet-Based System
- 289 Downloads
To achieve linear delivery of a highly water-soluble oral drug, verapamil, with a nanofibrous sheet-based system.
The nanofibrous sheets made of poly (lactic-co-glycolic acid) were used as a diffusion barrier to cap a tablet containing verapamil. For controlled drug delivery, we varied the sheet thickness to 20 μm, 50 μm and 80 μm to give the capped drug tablets, 20CT, 50CT and 80CT, respectively.
Drug release was more sustained as the sheet thickness increased. Thus, the periods for almost complete drug release could be extended up to 14 h with the 80 μm-thick sheets. As we assessed the linear least square fits to the in vitro drug release data from the capped tablets, 20CT and 50CT showed a fairly good correlation with linear release. The periods of linear release were 6 h and 8 h for 20CT and 50CT, respectively, both releasing more than 85% drug during this period.
We conclude that a drug tablet capped with nanofibrous sheets is a promising system for linear delivery of a highly water-soluble oral drug.
Key Wordslinear drug delivery nanofibrous sheet poly (lactic-co-glycolic acid) verapamil water-soluble drug
tablet capped with 20 μm-thick nanofibrous sheets
tablet capped with 50 μm-thick nanofibrous sheets
tablet capped with 80 μm-thick nanofibrous sheets
osmotic-controlled release oral delivery system
phosphate buffered saline
poly (lactic-co-glycolic acid)
Acknowledgments & DISCLOSURES
This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A110962) and grant no 03-2011-0110 from the SNUH Research Fund. The authors thank Hwaryong Kim at the Department of Biomedical Engineering in Seoul National University Hospital for preparation of the aligning and bonding stamps.
- 19.Sharma S, Bhardwaj S, Gaurave MK, Gupta G. Osmotic controlled drug delivery system. Latest Rev. 2008;6:3.Google Scholar
- 20.Park CG, Kim E, Park M, Park JH, Choy YB. A nanofibrous sheet based system for linear delivery of nifedipine. J Control Release. 2010.Google Scholar
- 26.Mex RSQ. Effect of formulation variables on verapamil hydrochloride release from hydrated HPMC matrices. Rev Soc Quim Mex. 2004;48:326–31.Google Scholar
- 32.Rautio J, Mannhold R, Kubinyi H. Prodrugs and Targeted Delivery: Towards Better ADME Properties: Wiley-VCH; 2011.Google Scholar
- 36.Yan B, Lu X, Lozano R. Feasibility study on qualification of USP dissolution apparatus 1 and 2 using the enhanced mechanical calibration procedure. Dissolut Technol. 2011;18(2):17–23.Google Scholar
- 37.NIHS. Guideline for bioequivalence studies for different strengths of oral solid dosage forms. Japan 2000.Google Scholar