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Linear Delivery of Verapamil via Nanofibrous Sheet-Based System

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Abstract

Purpose

To achieve linear delivery of a highly water-soluble oral drug, verapamil, with a nanofibrous sheet-based system.

Methods

The nanofibrous sheets made of poly (lactic-co-glycolic acid) were used as a diffusion barrier to cap a tablet containing verapamil. For controlled drug delivery, we varied the sheet thickness to 20 μm, 50 μm and 80 μm to give the capped drug tablets, 20CT, 50CT and 80CT, respectively.

Results

Drug release was more sustained as the sheet thickness increased. Thus, the periods for almost complete drug release could be extended up to 14 h with the 80 μm-thick sheets. As we assessed the linear least square fits to the in vitro drug release data from the capped tablets, 20CT and 50CT showed a fairly good correlation with linear release. The periods of linear release were 6 h and 8 h for 20CT and 50CT, respectively, both releasing more than 85% drug during this period.

Conclusion

We conclude that a drug tablet capped with nanofibrous sheets is a promising system for linear delivery of a highly water-soluble oral drug.

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Abbreviations

20CT:

tablet capped with 20 μm-thick nanofibrous sheets

50CT:

tablet capped with 50 μm-thick nanofibrous sheets

80CT:

tablet capped with 80 μm-thick nanofibrous sheets

DCM:

dichloromethane

DMF:

dimethylformamide

GI:

gastrointestinal

HPMC:

hydroxypropyl methylcellulose

IERs:

ion-exchange resins

NCT:

non-capped tablet

OROS:

osmotic-controlled release oral delivery system

PBS:

phosphate buffered saline

PLGA:

poly (lactic-co-glycolic acid)

THF:

tetrahydrofuran

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Acknowledgments & DISCLOSURES

This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A110962) and grant no 03-2011-0110 from the SNUH Research Fund. The authors thank Hwaryong Kim at the Department of Biomedical Engineering in Seoul National University Hospital for preparation of the aligning and bonding stamps.

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Authors and Affiliations

  1. Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, 152-742, Republic of Korea

    Ji Eun Lee, Chun Gwon Park, Myung Hun Kim, Min Park, Seung Ho Lee & Young Bin Choy

  2. Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea

    Byeong Moo An & Young Bin Choy

  3. Department of Biomedical Engineering, College of Medicine Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, 110-799, Republic of Korea

    Young Bin Choy

Authors
  1. Ji Eun Lee
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  2. Chun Gwon Park
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  3. Byeong Moo An
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  4. Myung Hun Kim
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  5. Min Park
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Corresponding author

Correspondence to Young Bin Choy.

Additional information

Ji Eun Lee and Chun Gwon Park contributed equally to this work.

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Lee, J.E., Park, C.G., An, B.M. et al. Linear Delivery of Verapamil via Nanofibrous Sheet-Based System. Pharm Res 29, 1787–1796 (2012). https://doi.org/10.1007/s11095-012-0702-z

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  • DOI: https://doi.org/10.1007/s11095-012-0702-z

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