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Pharmaceutical Research

, Volume 29, Issue 7, pp 1787–1796 | Cite as

Linear Delivery of Verapamil via Nanofibrous Sheet-Based System

  • Ji Eun Lee
  • Chun Gwon Park
  • Byeong Moo An
  • Myung Hun Kim
  • Min Park
  • Seung Ho Lee
  • Young Bin Choy
Research Paper

Abstract

Purpose

To achieve linear delivery of a highly water-soluble oral drug, verapamil, with a nanofibrous sheet-based system.

Methods

The nanofibrous sheets made of poly (lactic-co-glycolic acid) were used as a diffusion barrier to cap a tablet containing verapamil. For controlled drug delivery, we varied the sheet thickness to 20 μm, 50 μm and 80 μm to give the capped drug tablets, 20CT, 50CT and 80CT, respectively.

Results

Drug release was more sustained as the sheet thickness increased. Thus, the periods for almost complete drug release could be extended up to 14 h with the 80 μm-thick sheets. As we assessed the linear least square fits to the in vitro drug release data from the capped tablets, 20CT and 50CT showed a fairly good correlation with linear release. The periods of linear release were 6 h and 8 h for 20CT and 50CT, respectively, both releasing more than 85% drug during this period.

Conclusion

We conclude that a drug tablet capped with nanofibrous sheets is a promising system for linear delivery of a highly water-soluble oral drug.

Key Words

linear drug delivery nanofibrous sheet poly (lactic-co-glycolic acid) verapamil water-soluble drug 

Abbreviations

20CT

tablet capped with 20 μm-thick nanofibrous sheets

50CT

tablet capped with 50 μm-thick nanofibrous sheets

80CT

tablet capped with 80 μm-thick nanofibrous sheets

DCM

dichloromethane

DMF

dimethylformamide

GI

gastrointestinal

HPMC

hydroxypropyl methylcellulose

IERs

ion-exchange resins

NCT

non-capped tablet

OROS

osmotic-controlled release oral delivery system

PBS

phosphate buffered saline

PLGA

poly (lactic-co-glycolic acid)

THF

tetrahydrofuran

Notes

Acknowledgments & DISCLOSURES

This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A110962) and grant no 03-2011-0110 from the SNUH Research Fund. The authors thank Hwaryong Kim at the Department of Biomedical Engineering in Seoul National University Hospital for preparation of the aligning and bonding stamps.

Supplementary material

11095_2012_702_MOESM1_ESM.docx (189 kb)
ESM 1 (DOCX 189 kb)

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Ji Eun Lee
    • 1
  • Chun Gwon Park
    • 1
  • Byeong Moo An
    • 2
  • Myung Hun Kim
    • 1
  • Min Park
    • 1
  • Seung Ho Lee
    • 1
  • Young Bin Choy
    • 1
    • 2
    • 3
  1. 1.Interdisciplinary Program in Bioengineering, College of EngineeringSeoul National UniversitySeoulRepublic of Korea
  2. 2.Department of Biomedical Engineering, College of MedicineSeoul National UniversitySeoulRepublic of Korea
  3. 3.Department of Biomedical Engineering, College of Medicine Institute of Medical & Biological Engineering, Medical Research CenterSeoul National UniversitySeoulRepublic of Korea

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