Pharmaceutical Research

, Volume 27, Issue 6, pp 945–949 | Cite as

Current Trends in the Chemoprevention of Cancer

  • Fazlul H. Sarkar

In the latter part of the last century, we have witnessed the development of pharmaceutical agents for the treatment of human malignancies. During this development, active agents have been discovered from the bounties of nature, as well as from the hard work of synthetic medicinal chemists who have developed a synthetic chemical library of thousands of compounds. In recent years, we have also witnessed the discovery and synthesis of novel targeted agents for the treatment of human malignancies, some of which have shown excellent therapeutic superiority over conventional chemotherapeutic agents. However, we have not fully exploited what nature can offer in terms of novel agents. Such agents alone may not be sufficient as superior therapeutic agents, although “natural agents” (dietary agents) are by definition non-toxic, which could be very useful for sensitization of drug-resistant tumor cells to the existing conventional therapeutics. Moreover, such natural agents could also guide...


Resveratrol EGCG Natural Agent Human Malignancy Vorinostat 
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  1. 1.
    Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007;70:461–77.CrossRefPubMedGoogle Scholar
  2. 2.
    Newman DJ. Natural products as leads to potential drugs: an old process or the new hope for drug discovery? J Med Chem. 2008;51:2589–99.CrossRefPubMedGoogle Scholar
  3. 3.
    Douros J, Suffness M. New natural products of interest under development at the National Cancer Institute. Cancer Chemother Pharmacol. 1978;1:91–100.CrossRefPubMedGoogle Scholar
  4. 4.
    Douros J, Suffness M. The National Cancer Institute’s natural products antineoplastic development program. Recent Results Cancer Res. 1980;70:21–44.PubMedGoogle Scholar
  5. 5.
    Douros J, Suffness M. New natural products under development at the National Cancer Institute. Recent Results Cancer Res. 1981;76:153–75.PubMedGoogle Scholar
  6. 6.
    Douros J, Suffness M. New antitumor substances of natural origin. Cancer Treat Rev. 1981;8:63–87.CrossRefPubMedGoogle Scholar
  7. 7.
    Wall ME, Wani MC, Taylor H. Isolation and chemical characterization of antitumor agents from plants. Cancer Treat Rep. 1976;60:1011–30.PubMedGoogle Scholar
  8. 8.
    Wall ME, Wani MC. Antineoplastic agents from plants. Annu Rev Pharmacol Toxicol. 1977;17:117–32.CrossRefPubMedGoogle Scholar
  9. 9.
    Wall ME, Wani MC, Manikumar G, Abraham P, Taylor H, Hughes TJ et al. Plant antimutagenic agents, 2. Flavonoids. J Nat Prod. 1988;51:1084–91.CrossRefPubMedGoogle Scholar
  10. 10.
    Wall ME, Wani MC, Manikumar G, Hughes TJ, Taylor H, McGivney R et al. Plant antimutagenic agents, 3. Coumarins. J Nat Prod. 1988;51:1148–52.CrossRefPubMedGoogle Scholar
  11. 11.
    Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc. 1971;93:2325–7.CrossRefPubMedGoogle Scholar
  12. 12.
    Wani MC, Ronman PE, Lindley JT, Wall ME. Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. J Med Chem. 1980;23:554–60.CrossRefPubMedGoogle Scholar
  13. 13.
    Wang HK. Plant-derived anticancer agents currently in clinical use or in clinical trials. IDrugs. 1998;1:92–102.PubMedGoogle Scholar
  14. 14.
    Wall ME, Taylor H, Perera P, Wani MC. Indoles in edible members of the Cruciferae. J Nat Prod. 1988;51:129–35.CrossRefPubMedGoogle Scholar
  15. 15.
    Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci. 2005;78:431–41.CrossRefPubMedGoogle Scholar
  16. 16.
    Chin YW, Balunas MJ, Chai HB, Kinghorn AD. Drug discovery from natural sources. AAPS J. 2006;8:E239–53.PubMedGoogle Scholar
  17. 17.
    Cragg GM, Grothaus PG, Newman DJ. Impact of natural products on developing new anticancer agents. Chem Rev. 2009;109:3012–43.CrossRefPubMedGoogle Scholar
  18. 18.
    Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nat Rev Drug Discov. 2005;4:206–20.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Wayne State UniversityDetroitUSA

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