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Pharmaceutical Research

, Volume 26, Issue 1, pp 232–234 | Cite as

In Drug Delivery, Shape Does Matter

  • Samir Mitragotri
Editorial

Design and engineering of novel carriers for drug delivery has long been an area of active research (1). Numerous studies have been reported on engineering carriers for encapsulation of drugs, release, biocompatibility, clearance, and targeting. Researchers have long sought to define key design parameters that govern the performance of drug delivery carriers. Two parameters in particular, size and surface chemistry have been extensively studied. Several general guidelines have been established to guide the selection of size and surface chemistry to achieve the desired response. For example, nanoparticles with diameters less than 100 nm are considered suitable for tumor targeting via leaky vasculature (2). On the other hand, large microspheres (d > 40 μm) have been used as embolizing agents. Various guiding principles have also been established for selection of surface chemistry. For example, immobilization of polyethylene glycol on particles has been shown to reduce protein adsorption...

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Department of Chemical EngineeringUniversity of CaliforniaSanta BarbaraUSA

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