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Binding Constants of Maackia Amurensis Whole Extract and its Separate Flavanoids to Estradiol Receptors

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Pharmaceutical Chemistry Journal Aims and scope

Extract of Maackia amurensis containing genistein and resveratrol demonstrated competitive specific binding to estradiol receptors with more affinity for ERβ (average RBA = 6.25%) than for ERα (average RBA = 0.67%) in tests with experimental animals and clinical materials (endometrium biopsy). Associated flavonoids in the extract bound insignificantly to ERs although they could have a potentiating effect in the whole extract. Therefore, M. amurensis extract contained various phytoestrogens that determined the therapeutic potential (effect on cell growth, inflammation, apoptosis, angiogenesis, carbohydrate and lipid metabolism).

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Authors and Affiliations

  1. N. I. Pirogov Russian National Research Medical University, Ministry of Health of the RF, 1 Ostrovityanova St., Moscow, 117997, Russia

    E. N. Kareva & N. L. Shimanovskii

  2. I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF, 8/2 Trubetskaya St., Moscow, 119991, Russia

    E. N. Kareva, D. A. Tikhonov & S. E. Mironov

  3. G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences, 159 Prosp. 100 Let Vladivostoku, Vladivostok, 690022, Russia

    S. A. Fedoreev & N. I. Kulesh

Authors
  1. E. N. Kareva
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  2. D. A. Tikhonov
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  3. S. E. Mironov
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  4. S. A. Fedoreev
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  5. N. I. Kulesh
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  6. N. L. Shimanovskii
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 10, pp. 10 – 10, October, 2018.

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Kareva, E.N., Tikhonov, D.A., Mironov, S.E. et al. Binding Constants of Maackia Amurensis Whole Extract and its Separate Flavanoids to Estradiol Receptors. Pharm Chem J 52, 855–859 (2019). https://doi.org/10.1007/s11094-019-1914-x

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  • DOI: https://doi.org/10.1007/s11094-019-1914-x

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