Aseries of pyridine-3-carboxylic acid derivatives were synthesized via recyclization of a thiopyran ring using cyclic secondary amines and then converted into substituted thieno[2,3-b]pyridines. Studies of the neurotropic properties identified several synthesized compounds with anticonvulsant activity against corazole-induced seizures. The compounds were active as psychological sedatives and, in contrast with the tranquilizer diazepam, were inactive as central myorelaxants at anticonvulsant doses.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 10, pp. 22 – 27, October, 2018.
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Paronikyan, E.G., Ogannisyan, A.V., Paronikyan, R.G. et al. Synthesis and Neurotropic Activity of 4-Phenylpyridine-3-Carboxylic Acid and 3-Hydroxy-4-Phenylthieno[2,3-b]-Pyridine Derivatives. Pharm Chem J 52, 839–843 (2019). https://doi.org/10.1007/s11094-019-1911-0
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DOI: https://doi.org/10.1007/s11094-019-1911-0