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Radioprotective Efficiency of Recombinant Flagellin and Interleukin-1 Beta with Combined Administration

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The radioprotective efficacy of recombinant flagellin (FL) and interleukin-1 beta (IL-1) administered in combinations for preventive or therapeutic purposes was studied in experiments on white mongrel mice. The drugs were administered i.p. at doses of 1 mg/kg (FL) and 50 μg/kg (IL-1β). Simultaneous administration of the drugs in the early stages before irradiation was shown to be most efficacious in terms of 30-day survival of mice exposed to x-rays at a dose of 7.5 Gy (100% survival of mice vs. 53% survival in the control group, p < 0.01). Sequential administration of FL before exposure and IL-1β after exposure increased survival of the mice by 40% (p < 0.05). The results indicated that combined use of biotechnological drugs for radioprotection was promising.

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Authors and Affiliations

  1. S. M. Kirov Military Medical Academy, Ministry of Defense of the RF, St. Petersburg, 194044, Russia

    E. V. Murzina, G. A. Sofronov, N. V. Aksenova, O. M. Veselova & V. V. Zatsepin

  2. Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, 197376, Russia

    G. A. Sofronov & A. S. Simbirtsev

  3. Research Institute of Highly Pure Biopreparations, Federal Medical-Biological Agency, St. Petersburg, 197110, Russia

    A. S. Simbirtsev, A. M. Ishchenko & T. O. Antipova

Authors
  1. E. V. Murzina
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  2. G. A. Sofronov
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  3. A. S. Simbirtsev
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  4. A. M. Ishchenko
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  5. T. O. Antipova
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  6. N. V. Aksenova
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  7. O. M. Veselova
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  8. V. V. Zatsepin
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 10, pp. 18 – 21, October, 2018.

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Murzina, E.V., Sofronov, G.A., Simbirtsev, A.S. et al. Radioprotective Efficiency of Recombinant Flagellin and Interleukin-1 Beta with Combined Administration. Pharm Chem J 52, 835–838 (2019). https://doi.org/10.1007/s11094-019-1910-1

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  • DOI: https://doi.org/10.1007/s11094-019-1910-1

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