A series of novel polycyclic N-amidoimides were synthesized by reacting 4-oxatetracyclo[5.3.2.02,6.08,10]dodec-11-ene-3,5-dione with hydrazides of benzoic acids, arylaminoacetic acid, and oxalic acid. The most pronounced antiviral activities against Vaccinia virus were observed for 4-hydroxy-N-(3,5-dioxo-4-azatetracyclo[5.3.2.02, 6.08, 10]dodec-11-en-4-yl)-3-nitrobenzamide, N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)-N′-[(3-trifluoromethyl)phenyl]ethanediamide, and N-(2,6-dimethylphenyl)-N′-(3,5-dioxo-4-azatetracyclo-5.3.2.02,6,08,10]dodec-11-en-4-yl)ethanediamide.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 10, pp. 3 – 7, October, 2018.
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Selivanov, B.A., Bormotov, N.I., Shishkina, L.N. et al. Synthesis and Antiviral Activity of Polycyclic N-Amidoimides Based on 4-Oxatetracyclo-[5.3.2.02, 6.08, 10]Dodec-11-Ene-3,5-Dione. Pharm Chem J 52, 820–824 (2019). https://doi.org/10.1007/s11094-019-1907-9
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DOI: https://doi.org/10.1007/s11094-019-1907-9