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Influence of Lychnis chalcedonica L. Flavonoids on Transplanted Tumor Development and Cytostatic Therapy Effectiveness in Mice

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A complex of biologically active compounds was isolated from Lychnis chalcedonica L. cultivated at the Siberian Botanical Garden at Tomsk State University. HPLC analysis found that the isolated compounds were flavonoids with retention times 10.40, 12.45, 13.29, and 15.47 min. The major flavonoid constituent was vicenin with tr = 13.29 min and a peak area of 87.4%. The flavonoid complex of L. chalcedonica was studied using three transplanted tumor models, i.e., Lewis lung carcinoma (LLC), melanoma B-16 (B-16), and lung cancer RL-67 (RL-67). Tests on C57BL/6 mice showed that the L. chalcedonica flavonoid complex inhibited development of melanoma B-16. Co-administration of L. chalcedonica flavonoids and cyclophosphamide enhanced the antitumor effect of the cytostatic in animals with B-16, RL-67, and LLC.

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Acknowledgments

The work was performed in the framework of the Competitiveness Program of Tomsk State University.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, 3 Prosp. Lenina, Tomsk, 634028, Russia

    E. N. Amosova, E. P. Zueva, K. A. Lopatina, E. A. Safonova, T. G. Razina & O. Yu. Rybalkina

  2. Tomsk State University, 36 Prosp. Lenina, Tomsk, 634050, Russia

    K. A. Lopatina, E. A. Safonova, O. Yu. Rybalkina & L. N. Zibareva

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  1. E. N. Amosova
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  2. E. P. Zueva
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  3. K. A. Lopatina
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  4. E. A. Safonova
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  5. T. G. Razina
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  6. O. Yu. Rybalkina
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  7. L. N. Zibareva
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Corresponding author

Correspondence to E. P. Zueva.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 5, pp. 32 – 35, May, 2019.

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Amosova, E.N., Zueva, E.P., Lopatina, K.A. et al. Influence of Lychnis chalcedonica L. Flavonoids on Transplanted Tumor Development and Cytostatic Therapy Effectiveness in Mice. Pharm Chem J 53, 454–457 (2019). https://doi.org/10.1007/s11094-019-02018-8

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  • DOI: https://doi.org/10.1007/s11094-019-02018-8

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