Zoledronic acid is the drug substance of the highly efficient antiresorptive medicine Zometa. An improved synthesis of zoledronic acid via bis-phosphonation of 2-(1H-imidazol-1-yl)acetic acid is reported.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 3, pp. 50 – 52, March, 2019.
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Kuvaeva, Z.I., Lopatik, D.V. & Bondareva, O.M. Improved Process for Zoledronic Acid Synthesis. Pharm Chem J 53, 264–266 (2019). https://doi.org/10.1007/s11094-019-01989-y
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DOI: https://doi.org/10.1007/s11094-019-01989-y