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Modified Poly(T-Butyl Methacrylate) as a Doxorubicin Carrier for Targeted Delivery

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

Poly(t-butyl methacrylate) (PTBMA) was selected as a doxorubicin carrier for targeted delivery because it can hydrolyze to form water-soluble polymers. A chain-transfer reaction with thioglycolic acid was used. The thioglycolic acid concentration was 1 mass%, at which a polymer with the optimal biocompatibility (molecular mass ~12 kDa, polydispersion index Mw/Mn ≈ 1.5) was obtained. The polymer was chemically modified by a folate vector. The resulting polymer was converted via acid hydrolysis into a water-soluble copolymer. Then, a conjugate of doxorubicin (DOX) with the copolymer of t-butyl methacrylate and methacrylic acid modified by the folate vector on the terminal carboxylates was prepared. The degree of DOX conjugation to the polymer was 62.7 ± 11.8%. DOX was released from the polymer system almost three times faster at pH 4.6 than at pH 7.4. The cytotoxicity of the polymer conjugate was 1.52 μM.

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References

  1. A. Nori, K. D. Jensen, M. Tijerina, et al., Bioconjugate Chem., 14, 44 – 50 (2003).

    Article  CAS  Google Scholar 

  2. A. Gabizon, H. Shmeeda, and Y. Barenholz, Clin. Pharm., 42, 419 – 436 (2003).

    Article  CAS  Google Scholar 

  3. H. S. Yoo, K. H. Lee, J. E. Oh, and T. G. Park, J. Controlled Release, 68, 419 – 431 (2000).

    Article  CAS  Google Scholar 

  4. Y. Bae, T. A. Diezi, A. Zhao, and G. S. Kwon, J. Controlled Release, 122, 324 – 330 (2007).

    Article  CAS  Google Scholar 

  5. M. L. Adams, A. Lavasanifar, and G. S. Kwon, J. Pharm. Sci., 92, 1343 – 1355 (2003).

    Article  CAS  Google Scholar 

  6. G. Gaucher, R. H. Marchessault, and J. C. Leroux, J. Controlled Release, 143(1), 2 – 12 (2010).

    Article  CAS  Google Scholar 

  7. R. Duncan, Nat. Rev. Cancer, 6(9), 688 – 701 (2006).

    Article  CAS  Google Scholar 

  8. O. Zhukova and S. Bulgakova, J. Appl. Pharm. Sci., 6(7), 20 – 26 (2016).

    Article  CAS  Google Scholar 

  9. O. Zhukova and S. Bulgakova, Pharm. Chem. J., 48(12), 830 – 834 (2015).

    Article  CAS  Google Scholar 

  10. T. Mosmann, J. Immunol. Methods, 65(1–2), 55 – 63 (1983).

    Article  CAS  Google Scholar 

  11. F. M. Veronese, O. Schiavon, G. Pasut, et al., Bioconjugate Chem., 16, 775 (2005).

    Article  CAS  Google Scholar 

  12. N. Lavignac, J. L. Nicholls, P. Ferruti, and R. Duncan, Macromol. Biosci., 9, 480 – 487 (2009).

    Article  CAS  Google Scholar 

Download references

Acknowledgments

Equipment at the Common Use Center “Analytical Center IMKh RAS” (Nizhnii Novgorod) was used for the research. We thank Dr. O. V. Kuznetsova, senior scientist in the Laboratory of Physicochemical Analytical Methods IMKh RAS, for assistance in obtaining the IR spectra.

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Authors and Affiliations

  1. Privolzhsky Research Medical University, Ministry of Health of the Russian Federation, 10/1 Minina and Pozharskogo Sq, Nizhnii Novgorod, 603950, Russia

    O. V. Zhukova, T. F. Sergeeva & A. I. Gavrina

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  1. O. V. Zhukova
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  2. T. F. Sergeeva
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  3. A. I. Gavrina
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Correspondence to O. V. Zhukova.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 6, pp. 38 – 43, June, 2018.

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Zhukova, O.V., Sergeeva, T.F. & Gavrina, A.I. Modified Poly(T-Butyl Methacrylate) as a Doxorubicin Carrier for Targeted Delivery. Pharm Chem J 52, 539–544 (2018). https://doi.org/10.1007/s11094-018-1856-8

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  • DOI: https://doi.org/10.1007/s11094-018-1856-8

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