Pharmaceutical Chemistry Journal

, Volume 52, Issue 3, pp 257–265 | Cite as

Release Testing of Selected Drugs from Surface Magnetic Nanoparticles and Their Diffusion Through a Membrane

  • Ewelina Gronczewska
  • Weronika Worobiec
  • Alicja Defort
  • Andrzej Jurkowski
  • Jacek J. Kozioł
Article
  • 3 Downloads

In this study, magnetic nanoparticles were functionalized with dextran and immobilized ibuprofen, diclofenac, and dopamine in order to investigate the diffusion of drugs through a dialysis membrane under biological conditions such as a temperature of 37.0°C and pH 7.4. The concentration of released drugs was measured both inside the membrane and upon release into solution using spectrofluorimetric and spectrophotometric methods. The mechanism of drug release from the carrier was analyzed in terms of the Korsmeyer – Peppas model. The results show that differences in the mechanism of drug release depend on the time-diffusion process and the type of drug used. In addition, the atomic force microscopy and confocal microscopy methods were used to investigate the interaction between bacterial cells and functionalized nanoparticles.

Keywords

magnetic nanoparticles drug release diffusion membrane nonsteroidal anti-inflammatory drugs NSAIDs, dopamine, Korsmeyer – Peppas model, Lactobacillus bacteria 

Notes

Acknowledgments

The authors thank Dr. B. Zapotoczny for fruitful discussion of suggestions concerning drug release investigations.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ewelina Gronczewska
    • 1
  • Weronika Worobiec
    • 2
  • Alicja Defort
    • 2
  • Andrzej Jurkowski
    • 1
  • Jacek J. Kozioł
    • 1
    • 2
  1. 1.Faculty of Biological SciencesUniversity of Zielona GóraZielona GóraPoland
  2. 2.Innovation Center “Technologies for Human Health”Science and Technology Park of Zielona Góra University Ltd.Zielona GóraPoland

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