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Approaches to Pharmaceutical Analysis of an Innovative Liposomal Preparation for Treating Hepatitis C

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Pharmaceutical Chemistry Journal Aims and scope

The composite Y14/siUTR, a complex consisting of cationic lipopeptide Y14 as an excipient and pharmaceutical substance of small interfering RNAtargeted against the UTR region of hepatitis C virus (siUTR), was investigated. The composite was intended to inhibit the hepatitis C virus replication cycle. The present work was aimed at developing pharmaceutical analytical methods for the components of this composite using HPLC-UV and UV spectroscopy.

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Authors and Affiliations

  1. Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051, Russia

    V. V. Smirnov & L. M. Krasnykh

  2. Institute of Immunology, Federal Medico-Biological Agency of the Russian Federation, Moscow, 115478, Russia

    V. V. Smirnov, I. P. Shilovskii & M. R. Khaitov

  3. I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, 119991, Russia

    V. V. Smirnov, A. P. Ryzhenkova & V. N. Drozdov

Authors
  1. V. V. Smirnov
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  2. L. M. Krasnykh
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  3. I. P. Shilovskii
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  4. A. P. Ryzhenkova
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  5. M. R. Khaitov
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  6. V. N. Drozdov
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 3, pp. 59 – 61, March, 2018.

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Smirnov, V.V., Krasnykh, L.M., Shilovskii, I.P. et al. Approaches to Pharmaceutical Analysis of an Innovative Liposomal Preparation for Treating Hepatitis C. Pharm Chem J 52, 254–256 (2018). https://doi.org/10.1007/s11094-018-1802-9

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  • DOI: https://doi.org/10.1007/s11094-018-1802-9

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