Pharmaceutical Chemistry Journal

, Volume 52, Issue 3, pp 245–247 | Cite as

Comparative Dissolution Kinetics of Ibuprofen 200-Mg Capsules (Medisorb Co., Russia) and Ibuprofen 200-Mg Coated Tablets (Biosynthesis Co., Russia)

  • N. A. Prozorova
  • G. P. Vdovina
  • A. V. Bobrov

Experimental data on the comparative dissolution kinetics of two ibuprofen preparations from different manufacturers are presented. The study was performed in three buffer solutions at pH 1.2, 4.5, and 6.8 according to requirements of the Scientific Center for Expert Evaluation of Medicinal Products of the Russian Federation. A fourth dissolution medium was buffer solution at pH 7.2, which is included in a draft regulation. The test used a Erweka DT-720 rotating-basket device.


ibuprofen bioavailability dissolution in vitro 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • N. A. Prozorova
    • 1
    • 2
  • G. P. Vdovina
    • 1
  • A. V. Bobrov
    • 2
  1. 1.E. A. Wagner Perm State Medical UniversityPermRussia
  2. 2.Medisorb Co.PermRussia

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