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Pharmaceutical Chemistry Journal

, Volume 52, Issue 3, pp 241–244 | Cite as

Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin

  • I. I. KrasnyukJr
  • T. M. Kosheleva
  • A. V. Belyatskaya
  • I. I. Krasnyuk
  • O. I. Stepanova
  • Yu. Skovpen
  • V. V. Grikh
  • L. V. Ovsyannikova
Article
  • 19 Downloads

Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H2O. The solubility and dissolution rate of indomethacin from SDs increased by 1.8 – 2.2 and 3.1 – 4.4 times, respectively. Indomethacin became less crystalline and then amorphous during preparation of the SDs. Dissolution of the SDs solubilized indomethacin and formed colloidal solutions.

Keywords

indomethacin solid dispersions polyethylene glycol 1500 solubility crystallinity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • I. I. KrasnyukJr
    • 1
  • T. M. Kosheleva
    • 1
  • A. V. Belyatskaya
    • 1
  • I. I. Krasnyuk
    • 1
  • O. I. Stepanova
    • 1
  • Yu. Skovpen
    • 2
  • V. V. Grikh
    • 1
  • L. V. Ovsyannikova
    • 1
  1. 1.I. M. Sechenov First Moscow State Medical UniversityMoscowRussia
  2. 2.Rancho BioSciencesSan DiegoUSA

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