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Pharmaceutical Chemistry Journal

, Volume 52, Issue 3, pp 209–212 | Cite as

Glucokinase Activators Based on N-Aryl-N′-Pyridin-2-Ylurea Derivatives

  • A. V. Semenov
  • I. V. Tarasova
  • V. S. Khramov
  • E. V. Semenova
  • V. I. Inchina
  • S. S. Vakaeva
Article
  • 22 Downloads

A series of previously undescribed N-aryl-N′-pyridin-2-ylureas were prepared via the reaction of 2-aminopyridines with benzoyl azides and tested in vitro as activators of glucokinase. Statistically significant reductions of glucose levels as compared with controls were demonstrated for several compounds.

Keywords

glucokinase activators N-aryl-N-pyridin-2-ylurea 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • A. V. Semenov
    • 1
  • I. V. Tarasova
    • 1
  • V. S. Khramov
    • 1
  • E. V. Semenova
    • 1
  • V. I. Inchina
    • 1
  • S. S. Vakaeva
    • 1
  1. 1.N. P. Ogarev National Research Mordovia State UniversitySaranskRussia

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