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Effects of Pharmaceutical Preparations on the Rate of Degradation of Poly(Lactide-Co-Glycolide) Scaffolds

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

The effects of acetylsalicylic acid, ibuprofen, 6-methyluracil, and chondroitin sulfate impregnated in poly-(lactide-co-glycolide) scaffolds of different chemical compositions and molecular weights using supercritical carbon dioxide on the processes of scaffold degradation in phosphate-buffered saline pH 7.4 were studied and the rate constants of these processes were determined. Incorporation of acetylsalicylic acid and ibuprofen into poly(lactide-co-glycolide) scaffolds was found to produce significant increases in the rate of hydrolysis of the polymer base, while the presence of methyluracil and chondroitin sulfate had virtually no effect.

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Authors and Affiliations

  1. Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences, 2 Pionerskaya Street, Troitsk, 142190, Moscow, Russia

    E. N. Antonov, A. G. Dunaev, S. A. Minaeva, L. I. Krotova & V. K. Popov

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  1. E. N. Antonov
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  2. A. G. Dunaev
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  3. S. A. Minaeva
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  4. L. I. Krotova
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  5. V. K. Popov
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Correspondence to E. N. Antonov.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 1, pp. 39 – 46, January, 2018.

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Antonov, E.N., Dunaev, A.G., Minaeva, S.A. et al. Effects of Pharmaceutical Preparations on the Rate of Degradation of Poly(Lactide-Co-Glycolide) Scaffolds. Pharm Chem J 52, 69–76 (2018). https://doi.org/10.1007/s11094-018-1767-8

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  • DOI: https://doi.org/10.1007/s11094-018-1767-8

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