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Pharmaceutical Chemistry Journal

, Volume 52, Issue 1, pp 57–62 | Cite as

Antitumor Potential of Substances from the Fungus Ganoderma lucidum

  • E. S. Petrova
  • M. I. Rudina
  • Ya. Sh. Shvarts
MEDICINAL HERBS

We present here a review of published data mostly from the last 10 years on the antitumor activity of substances from the fungus Ganoderma lucidum. Its main biologically active components are described, particularly triterpenes, polysaccharides, glycoproteins, and proteoglycans. The mechanisms of the antitumor actions of these compounds in vitro and in vivo are discussed, these including blockade of the cell cycle, induction of apoptosis, decreases in the metastatic potential, suppression of angiogenesis, and immunomodulatory activity. The potential of using substances from G. lucidum for the treatment of oncological patients is assessed.

Keywords

Ganoderma lucidum antitumor activity triterpenes polysaccharides 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • E. S. Petrova
    • 1
    • 2
  • M. I. Rudina
    • 1
  • Ya. Sh. Shvarts
    • 3
  1. 1.Science Research Institute of Therapy and Prophylactic Medicine, Russian Academy of SciencesNovosibirskRussia
  2. 2.Institute of Solid Body Chemistry and Mechanistic ChemistryNovosibirskRussia
  3. 3.Novosibirsk Science Research Institute of Tuberculosis, Russian Ministry of HealthNovosibirskRussia

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