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Antitumor Potential of Substances from the Fungus Ganoderma lucidum

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Pharmaceutical Chemistry Journal Aims and scope

We present here a review of published data mostly from the last 10 years on the antitumor activity of substances from the fungus Ganoderma lucidum. Its main biologically active components are described, particularly triterpenes, polysaccharides, glycoproteins, and proteoglycans. The mechanisms of the antitumor actions of these compounds in vitro and in vivo are discussed, these including blockade of the cell cycle, induction of apoptosis, decreases in the metastatic potential, suppression of angiogenesis, and immunomodulatory activity. The potential of using substances from G. lucidum for the treatment of oncological patients is assessed.

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Authors and Affiliations

  1. Science Research Institute of Therapy and Prophylactic Medicine, Russian Academy of Sciences, 175/1 B. Bogatkov Street, 630089, Novosibirsk, Russia

    E. S. Petrova & M. I. Rudina

  2. Institute of Solid Body Chemistry and Mechanistic Chemistry, 18 Kutateladze Street, 630128, Novosibirsk, Russia

    E. S. Petrova

  3. Novosibirsk Science Research Institute of Tuberculosis, Russian Ministry of Health, 81a Okhotskaya Street, 630040, Novosibirsk, Russia

    Ya. Sh. Shvarts

Authors
  1. E. S. Petrova
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  2. M. I. Rudina
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  3. Ya. Sh. Shvarts
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 1, pp. 33 – 38, January, 2018.

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Petrova, E.S., Rudina, M.I. & Shvarts, Y.S. Antitumor Potential of Substances from the Fungus Ganoderma lucidum. Pharm Chem J 52, 57–62 (2018). https://doi.org/10.1007/s11094-018-1765-x

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  • DOI: https://doi.org/10.1007/s11094-018-1765-x

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