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Pharmaceutical Chemistry Journal

, Volume 52, Issue 1, pp 37–41 | Cite as

Acetoxybenzoylglycylglycines as Potential Cerebroprotective Compounds

  • A. K. Brel’
  • I. N. Tyurenkov
  • S. V. Lisina
  • S. S. Popov
  • D. V. Verkholyak
  • Yu. N. Budaeva
  • E. V. Volotova
  • N. V. Atapina
  • D. V. Kurkin
Article
  • 17 Downloads

3,4,5-Trimethoxy- and 2-, 3-, and 4-acetoxybenzoylglycylglycines and their water-soluble potassium and lithium salts were synthesized. The cerebroprotective properties of the water-soluble potassium and lithium salts of acetoxybenzoylglycylglycines were studied experimentally. The most marked cerebroprotective proteins in cerebral ischemia were found with the lithium salt of 2-acetoxybenzoylglycylglycine.

Keywords

carbonic acid amides hydroxybenzoic acid derivatives cerebroprotective agents synthesis 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • A. K. Brel’
    • 1
  • I. N. Tyurenkov
    • 1
  • S. V. Lisina
    • 1
  • S. S. Popov
    • 1
  • D. V. Verkholyak
    • 1
  • Yu. N. Budaeva
    • 1
  • E. V. Volotova
    • 1
  • N. V. Atapina
    • 1
  • D. V. Kurkin
    • 1
  1. 1.Volgograd State Medical University, Ministry of Health of the Russian FederationVolgogradRussia

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