Pharmaceutical Chemistry Journal

, Volume 51, Issue 11, pp 1021–1024 | Cite as

Interchangeability Issues with Glaucoma Medicines Using Latanoprost as an Example

  • N. D. Bunyatyan
  • O. V. Filippova
  • B. K. Romanov
  • A. B. Prokof’ev
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The possible interchangeability of eye drops was analyzed using glaucoma medicines containing latanoprost as examples. It was shown that the reference and generic drugs could be identical with respect to composition of active ingredients when manufactured from the same pharmaceutical substance but could differ in the excipient composition, in particular, have a different buffer and osmolality that could produce differences in their clinical effects. An analysis of the literature showed that the therapeutic efficacy and safety could vary for pharmaceutically equivalent drugs. The lack of therapeutic equivalence on the background of pharmaceutical equivalence could be caused by the use of different packaging and different dosing systems. Therefore, results from clinical trials must be compared to confirm the interchangeability of eye drops.

Keywords

generic drugs interchangeability glaucoma eye drops latanoprost excipients 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • N. D. Bunyatyan
    • 1
    • 2
  • O. V. Filippova
    • 1
  • B. K. Romanov
    • 1
  • A. B. Prokof’ev
    • 2
  1. 1.Institute of Professional Education, I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaMoscowRussia
  2. 2.Scientific Center for Expert Evaluation of Medicinal ProductsMinistry of Health of the Russian FederationMoscowRussia

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