New factor-Xa inhibitors in a series of pyrrolo[3,2,1-ij]quinoline-1,2-diones substituted by condensation at the β-carbonyl with rhodanine, arylamines, and H-tryptamines were synthesized, characterized, and studied by molecular docking. Promising factor-Xa inhibitors with inhibitory constants in the micromolar concentration range (IC50 = 0.7 – 40 μM) were discovered.
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Acknowledgments
New compounds were synthesized with support of the FTP “Research and development in priority directions for development of the Russian science and technology complex for 2014 – 2020 (Contract No. 14.577.21.0182, unique identifier of applied scientific research RFMEFI57715X0182). Molecular docking and post-processing studies for discovering and designing new inhibitors were supported by RSF Grant 14 – 50 – 00029.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 11, pp. 19 – 23, November, 2017.
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Medvedeva, S.M., Potapov, A.Y., Gribkova, I.V. et al. Synthesis, Docking, and Anticoagulant Activity of New Factor-Xa Inhibitors in a Series of Pyrrolo[3,2,1-ij]Quinoline-1,2-Diones. Pharm Chem J 51, 975–979 (2018). https://doi.org/10.1007/s11094-018-1726-4
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DOI: https://doi.org/10.1007/s11094-018-1726-4