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Pharmaceutical Chemistry Journal

, Volume 50, Issue 10, pp 678–683 | Cite as

Synthesis of Pyrimidino Derivatives: Potent Antimicrobial Candidates

  • R. Chauhan
  • A. A. Siddiqi
  • J. Dwivedi
DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY

A series of pyimidino derivatives including 4,5-dihydro-5-(1H-indol-1-yl)-6-(phenyl)-4-(4-substituted phenyl) pyrimidine-2-(1H)-one/thione and 4,5-dihydro-4-(3,4,5-trimethoxyphenyl)-6-phenyl-5-[3-(substitute-1-yl))-1H-indol-1-yl]pyrimidin-2(1H)-one/thione have been synthesis and their antimicrobial activity has been assessed in order to study the antimicrobial synergism of indole and benzene nuclei in single molecule. The structures of synthesized compounds were confirmed by IR, NMR and mass spectroscopy data. Antimicrobial activity assessment gives comparable to excellent results against all test microbes. It is concluded that nuclei separately possessing antimicrobial activity exhibit synergism when combined in a single molecule.

Keywords

pyrimidino derivatives chalcones antibacterial activity antifungal activity synergism future aspects 

Notes

Acknowledgments

The authors are thankful to Banasthali University Rajasthan for providing teaching fund. The paper is the part of Ph.D. Thesis of one of the authors, Rajani Chauhan.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of PharmacyBanasthali UniversityTonkIndia
  2. 2.Department of PharmacyJamia Hamdard UniversityNew DelhiIndia
  3. 3.Department of ChemistryBanasthali UniversityTonkIndia

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