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Pharmaceutical Chemistry Journal

, Volume 50, Issue 10, pp 631–636 | Cite as

Influence of Polyuronides on Biological Oxidation, Liver Antitoxic Functions, and Erythrocyte Membrane Condition in Lead-Intoxicated Rats

  • N. Sh. Kaisheva
  • Yu. K. Vasilenko
  • A. Sh. Kaishev
MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
  • 52 Downloads

The influence of pectin and laminarid NP complex on biological oxidation processes in lead-intoxicated rats was estimated using parameters such as oxidative phosphorylation, ATP synthesis, activities of biological oxidation enzymes, lipid peroxidation, and erythrocyte resistance to osmotic shock and oxidation by oxygen in air, liver antitoxic function, and blood hematological indices. It was established that the polyuronides exhibited antihypoxic, antioxidant, and membrane-stabilizing action.

Keywords

polyuronides biological oxidation intoxication with Pb(II) ions pharmacological activity 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • N. Sh. Kaisheva
    • 1
  • Yu. K. Vasilenko
    • 1
  • A. Sh. Kaishev
    • 1
  1. 1.Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University, Russian Ministry of HealthPyatigorskRussia

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