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Pharmaceutical Chemistry Journal

, Volume 50, Issue 9, pp 600–602 | Cite as

Local Anesthetic Activity of a Promising Piperidine Derivative (LAS-54) in Combination with Epinephrine

  • G. M. Pichkhadze
  • G. S. Smagulova
  • D. M. Kadyrova
  • K. D. Praliev
  • V. K. Yu
Article
  • 40 Downloads

Results from studies of the local anesthetic activity of LAS-54 [4-(benzoyloxy)-3-butoxypiperidinium chloride] (synthesized at the Laboratory of the Chemistry of Synthetic and Natural Drugs, Bekturov Institute of Chemical Sciences) in combination with epinephrine are presented. It was found that joint application of the vasoconstrictor with LAS-54, especially at low concentrations, prolonged infiltration, conduction, and spinal anesthesia.

Keywords

conduction, infiltration, and spinal anesthesia piperidine vasoconstrictor epinephrine 

References

  1. 1.
    A. Zh. Petrikas, V. A. Egorova, and K. V. Ermilova, Stomatologiya, No. 5, 24 – 26 (2009).Google Scholar
  2. 2.
    T. V. Tregubova, Local Anesthesia in Ambulatory Dental Surgery [in Russian], Uchebnoe Posobie, Almaty (2007), pp. 29 – 32.Google Scholar
  3. 3.
    A. I. Levshankov, Ambulatornaya Khirurgiya: Statsionarozameshchayushchie Tekhnol., No. 1, 6 – 12 (2005).Google Scholar
  4. 4.
    E. V. Zoryan and S. A. Rabinovich, Klin. Farmakol., No. 4, 45 – 49 (2008).Google Scholar
  5. 5.
    R. U. Amiraev and P. A. Galenko-Yaroshevskii, Med. Farm., No. 1, 43 – 46 (2002).Google Scholar
  6. 6.
    R. U. Amiraev, Author’s Abstract of a Candidate Dissertation, (2004), p. 122.Google Scholar
  7. 7.
    T. K. Supiev, N. M. Masalina, and M. B. Masalina, Probl. Stomatol., No. 3, 17 – 21 (2005).Google Scholar
  8. 8.
    K. D. Praliev and K. V. Yu, Proceedings of the ICS, MES, RK “Chemistry of Natural and Synthetic Biologically Active Compounds (Structure, Transformations and Properties)” [in Russian], Almaty (2001), Vol. 76, pp. 4 – 15.Google Scholar
  9. 9.
    K. D. Praliev, V. K. Yu, et al., RK Pat. No. 2106, “1-(3-n-Butoxypropyl)- 4-benzoyloxypiperidine with local anesthetic activity”; Byull. Izobret., No. 1 (1996).Google Scholar
  10. 10.
    R. S. Kuzdenbaeva, K. D. Rakhimov, S. N. Shin, and G. N. Chukanova, Preclinical Study of the Local Anesthetic Activity of New Biologically Active Compounds. Methodical Aide [in Russian], Almaty (2000), p. 30.Google Scholar
  11. 11.
    D. D. Ignatov, V. A. Volchkov, P. A. Galenko-Yaroshevskii, et al., “Methodical Recommendations for Studying Local Anesthetic Activity of Drugs,” in: Handbook for Preclinical Drug Trials [in Russian], Part 1, Grif i K, Moscow (2012), pp. 334 – 362.Google Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • G. M. Pichkhadze
    • 1
  • G. S. Smagulova
    • 1
  • D. M. Kadyrova
    • 1
  • K. D. Praliev
    • 2
  • V. K. Yu
    • 2
  1. 1.S. D. Asfendiyarov Kazakh National Medical UniversityAlmatyKazakhstan
  2. 2.A. B. Bekturov Institute of Chemical SciencesMinistry of Education and Science of the Republic of KazakhstanAlmatyKazakhstan

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