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Pharmaceutical Chemistry Journal

, Volume 50, Issue 8, pp 537–542 | Cite as

Development of Manufacturing Technology for Prolonged-Release Oral Amben Preparation

  • G. O. Nifontova
  • S. P. Krechetov
  • E. V. Korostylev
  • A. R. Akhmetzyanova
  • I. I. Krasnyuk
DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
  • 62 Downloads

Results from technology development for manufacturing an amben prolonged-release preparation based on a Kollidon SR hydrophobic polymer matrix were presented. It was shown that dry and wet granulation could improve the processing properties of mixtures for preparing tablets and provide the required amben release kinetics.

Keywords

hydrophobic polymer matrix amben prolonged release granulation 

Notes

Acknowledgments

The work was supported financially by the RF Ministry of Education and Science (Contract No. 02.G25.31.0001) under the auspices of RF Administration Decree No. 218 of Apr. 9, 2010, and utilized equipment of the Center for Collective Use of Unique Scientific Equipment for MPTI nanotechnology studies.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • G. O. Nifontova
    • 1
    • 2
  • S. P. Krechetov
    • 1
  • E. V. Korostylev
    • 3
  • A. R. Akhmetzyanova
    • 4
  • I. I. Krasnyuk
    • 2
  1. 1.Life Sciences Center, Moscow Institute of Physics and Technology (Technical University)Moscow OblastRussia
  2. 2.I. M. Sechenov First Moscow State Medical UniversityMoscowRussia
  3. 3.Moscow Institute of Physics and Technology (Technical University)Moscow OblastRussia
  4. 4.Farmzashchita Research and Production CenterFederal Medico-Biological Agency of the Russian FederationMoscow OblastRussia

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