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Pharmaceutical Chemistry Journal

, Volume 50, Issue 5, pp 315–319 | Cite as

Effect of Serratula Coronata Extract on Apoptosis Activity in Rats

  • K. E. Selyaskin
  • Yu. S. Sidorova
  • S. N. Zorin
  • L. S. Vasilevskaya
  • S. O. Volodina
  • V. V. Volodin
  • V. K. Mazo
MEDICINAL PLANTS
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Phytoecdysteroids (at doses of 5 and 15 mg/kg of body mass per day) in the aqueous extract of Serratula coronata L. were administered toWistar rats for 15 d, did not have adverse effects on the thymus, and did not increase apoptosis rat in heart, brain, and thymus cells. The apoptosis rate in thymus cells of animals exposed to an electric shock increased statistically significantly relative to intact controls. The thymus mass did not decrease statistically significantly in stressed rats that received the phytoecdysteroid extract as compared with stressed animals that did not receive it. The apoptosis rate characterized by the DNA-damage level and number of apoptotic cells was also diminished in the thymus of stressed rats that received the extract. The results confirmed the safety of using phytoecdysteroid extracts in food and indicated that this extract inhibited the general adaptation syndrome of the rats.

Keywords

phytoecdysteroids apoptosis thymus Serratula coronata L. aqueous extract adaptogens 

Notes

Acknowledgments

The work was sponsored partially by the RAS Presidium Program “Living Nature: Current Condition and Development Problems” on the topic “Resources of ecdysteroid-containing plants in the flora of Vietnam and studies of the adaptogenic activity of biologically active additives containing phytoecdysteroids on the work capacity of people under high physical and psychiatric stress” (15-12-4-59) and a grant of the RAS UrB Program “Assessment of Stress Response and Correction of Adaptive Reaction of Highly Productive Ruminants by Plant Adaptogens and Under Northern Conditions.”

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • K. E. Selyaskin
    • 1
  • Yu. S. Sidorova
    • 1
  • S. N. Zorin
    • 1
  • L. S. Vasilevskaya
    • 1
  • S. O. Volodina
    • 2
  • V. V. Volodin
    • 2
  • V. K. Mazo
    • 1
  1. 1.Scientific Research Institute of NutritionRussian Academy of Medical SciencesMoscowRussia
  2. 2.Institute of Biology, Komi Scientific CenterUral Branch of the Russian Academy of SciencesSyktyvkarRussia

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