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Pharmaceutical Chemistry Journal

, Volume 50, Issue 4, pp 226–228 | Cite as

Synthesis and Analgesic Activity of N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides

  • V. L. Gein
  • T. M. Zamaraeva
  • N. A. Buzmakova
  • B. Ya. Syropyatov
  • N. V. Alikina
Article

A three-component reaction of acetoacetanilides with a mixture of an aromatic aldehyde and thiourea was used to synthesize previously unknown N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides, which had high analgesic activity and low acute toxicity.

Keywords

N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides analgesic activity acute toxicity 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • V. L. Gein
    • 1
  • T. M. Zamaraeva
    • 1
  • N. A. Buzmakova
    • 1
  • B. Ya. Syropyatov
    • 1
  • N. V. Alikina
    • 1
  1. 1.Perm State Pharmaceutical Academy, Ministry of Health of the Russian FederationPermRussia

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