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Pharmaceutical Chemistry Journal

, Volume 49, Issue 9, pp 598–601 | Cite as

Synthesis and Antimicrobial Activity of Thietanylpyrimidin-2,4(1H,3H)-Dione Acetanilides and Acetylhydrazones

  • S. A. Meshcheryakova
  • V. A. Kataev
  • I. Ya. Fattakhova
  • K. V. Nikolaeva
  • A. K. Bulgakov
Article

Alkylation of 6-methyl-1-(thietan-3-yl)pyrimidine-2,4(1H,3H)-dione with chloroacetanilides yielded N-acetanilide derivatives. Interaction of 2-(4-methyl-2,6-dioxo-3-thietan-3-yl-3,6-dihydropyrimidin-1(2H)acetohydrazide with carbonyl compounds was used to synthesize arylaldehyde and ketone N-acetylhydrazones. The antimicrobial and antifungal activities of the compounds synthesized here were studied.

Keywords

thietane pyrimidin-2,4-(1H,3H)-dione N-acetanilides N-acetylhydrazones E, Z isomerism antimicrobial and antifungal activity 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • S. A. Meshcheryakova
    • 1
  • V. A. Kataev
    • 1
  • I. Ya. Fattakhova
    • 1
  • K. V. Nikolaeva
    • 1
  • A. K. Bulgakov
    • 1
  1. 1.Bashkir State Medical UniversityUfaRussia

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