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Pharmaceutical Chemistry Journal

, Volume 49, Issue 8, pp 515–518 | Cite as

Synthesis and Antioxidant Activity of Ammonium Salts of 4-(3-Bromophenyl)-5-Methoxycarbonyl-1-(N,N-Dimethylaminopropyl)-3,4-Dihydropyrimidin-2-(1H)-One

  • O. V. Kushnir
  • O. N. Voloshchuk
  • M. M. Marchenko
  • M. V. Vovk
Article
  • 71 Downloads

Methyl-3-{[2-(dimethylamino)propyl]amino}acrylate reacted with α-chloro-3-bromobenzylisocyanate to synthesize 4-(3-bromophenyl)-5-methoxycarbonyl-1-(N,N-dimethylaminopropyl)-3,4-dihydropyrimidin-2(1H)-one hydrochloride, alkylation of which by chloroacetate esters yielded a series of quaternary ammonium salts. The structures of the compounds were confirmed by IR and PMR spectroscopy and mass spectrometry. Some of the synthesized compounds exhibited high inhibitory activity with respect to the superoxide-generating ability of mitochondria in both the liver and transformed tissue of tumor-bearing rats.

Keywords

3,4-dihydropyrimidin-2-ones quaternization ammonium salts antioxidant activity superoxide anion-radical superoxide-generating activity Guerin carcinoma 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • O. V. Kushnir
    • 1
  • O. N. Voloshchuk
    • 1
  • M. M. Marchenko
    • 1
  • M. V. Vovk
    • 2
  1. 1.Chernovtsy National UniversityChernovtsyUkraine
  2. 2.Institute of Organic ChemistryNational Academy of Sciences of UkraineKievUkraine

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