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Pharmaceutical Chemistry Journal

, Volume 49, Issue 2, pp 91–95 | Cite as

Synthesis and Antimicrobial and Protistocidal Activity of 1-(2-Aryloxyethyl- and 2-Halobenzyl)-3-(2-Hydroxyethyl)-2-Imino-1,3-Dihydrobenzimidazolines

  • L. N. Divaeva
  • A. I. Klimenko
  • A. S. Morkovnik
  • L. N. Fetisov
  • T. A. Kuz’menko
  • A. A. Zubenko
  • M. A. Bodryakova
  • A. N. Bodryakov
Article

New 1-(2-aryloxyethyl- and 2-halobenzyl)-3-(2-hydroxyethyl)-2-imino-1,3-dihydrobenzimidazoline hydrochlorides were synthesized via reactions of 1-(2-aryloxyethyl- and 2-halobenzyl)-2-aminobenzimidazoles with ethylenechlorohydrin. These compounds were shown to possess both bactericidal activity against some pathogenic Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli) and pronounced protistocidal activity against the species Colpoda steinii.

Keywords

1-(2-aryloxyethyl- and 2-halobenzyl)-2-aminobenzimidazoles 1-(2-aryloxyethyl- and 2-halobenzyl)-3-(2-hydroxyethyl)-2-imino-1,3-dihydrobenzimidazoline hydrochlorides synthesis antibacterial activity Staphylococcus aureus Escherichia coli protistocidal activity Colpoda steinii 

Notes

Acknowledgments

The work was performed under a project of a state contract for scientific activity of IPOC, SFU, Project No. 4.196.2014/K. Equipment of the CCU Molecular Spectroscopy, IPOC, SFU, was used in the work.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • L. N. Divaeva
    • 1
  • A. I. Klimenko
    • 2
  • A. S. Morkovnik
    • 1
  • L. N. Fetisov
    • 2
  • T. A. Kuz’menko
    • 1
  • A. A. Zubenko
    • 2
  • M. A. Bodryakova
    • 2
  • A. N. Bodryakov
    • 2
  1. 1.Institute of Physical and Organic ChemistrySouthern Federal UniversityRostov-on-DonRussia
  2. 2.North-Caucasian Regional Scientific Research Veterinary Institute (NCRSRVI)NovocherkasskRussia

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