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Synthesis and Antimicrobial and Protistocidal Activity of 1-(2-Aryloxyethyl- and 2-Halobenzyl)-3-(2-Hydroxyethyl)-2-Imino-1,3-Dihydrobenzimidazolines

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Pharmaceutical Chemistry Journal Aims and scope

New 1-(2-aryloxyethyl- and 2-halobenzyl)-3-(2-hydroxyethyl)-2-imino-1,3-dihydrobenzimidazoline hydrochlorides were synthesized via reactions of 1-(2-aryloxyethyl- and 2-halobenzyl)-2-aminobenzimidazoles with ethylenechlorohydrin. These compounds were shown to possess both bactericidal activity against some pathogenic Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli) and pronounced protistocidal activity against the species Colpoda steinii.

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Notes

  1. Here and further primed numbers denote positions on the N1-aryl substituent.

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Acknowledgments

The work was performed under a project of a state contract for scientific activity of IPOC, SFU, Project No. 4.196.2014/K. Equipment of the CCU Molecular Spectroscopy, IPOC, SFU, was used in the work.

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Authors and Affiliations

  1. Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, 344090, Russia

    L. N. Divaeva, A. S. Morkovnik & T. A. Kuz’menko

  2. North-Caucasian Regional Scientific Research Veterinary Institute (NCRSRVI), Novocherkassk, 346421, Russia

    A. I. Klimenko, L. N. Fetisov, A. A. Zubenko, M. A. Bodryakova & A. N. Bodryakov

Authors
  1. L. N. Divaeva
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  2. A. I. Klimenko
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  3. A. S. Morkovnik
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  4. L. N. Fetisov
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  5. T. A. Kuz’menko
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  6. A. A. Zubenko
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  7. M. A. Bodryakova
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  8. A. N. Bodryakov
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Corresponding author

Correspondence to L. N. Divaeva.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 2, pp. 21 – 25, February, 2015.

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Divaeva, L.N., Klimenko, A.I., Morkovnik, A.S. et al. Synthesis and Antimicrobial and Protistocidal Activity of 1-(2-Aryloxyethyl- and 2-Halobenzyl)-3-(2-Hydroxyethyl)-2-Imino-1,3-Dihydrobenzimidazolines. Pharm Chem J 49, 91–95 (2015). https://doi.org/10.1007/s11094-015-1228-6

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  • DOI: https://doi.org/10.1007/s11094-015-1228-6

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