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Pharmaceutical Chemistry Journal

, Volume 48, Issue 12, pp 819–821 | Cite as

Sterilizing Filtration for Production of Strontium-82 Active Pharmaceutical Ingredient

  • D. V. Stepchenkov
  • A. A. Semenova
  • E. G. Kuz’mina
  • A. A. Kuznetsov
  • N. M. Rogova
  • S. V. Kham’yanov
  • N. A. Nerozin
Article
  • 52 Downloads

Sterilizing filtration for the production of strontium-82 obtained after radiochemical processing of irradiated rubidium-metal targets was developed. Pharmacopoeial microbiology sterility tests established that the process produced sterile Sr-82 active pharmaceutical ingredient and could be recommended for producing 82Sr/82Rb generators.

Keywords

nuclear medicine strontium-82 sterilizing filtration active pharmaceutical ingredient 82Sr/82Rb generator 

Notes

Acknowledgments

The work was sponsored by the Ministry of Education and Science of the Russian Federation on the topic “Development of manufacturing technology for strontium-82, raw material for producing radiopharmaceuticals” under State Contract No. 16.522.12.2012.

References

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    B. L. Zhujkov, V. M. Kokhanjuk, and D. Vinsent, RU Pat. No. 2,102,808, Jan. 20, 1998 [see also B. L. Zhuikov, V. M. Kokhanjuk, and J. Vincent, US Pat. No. 5, 875, 220, Feb. 23, 1999].Google Scholar
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    Rubidium Chloride Rb 82 Injection, U. S. Pharmacopoeia, 29, 1936 (2009).Google Scholar
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    OFS 42-0066-07 Sterility, Russian Federation State Pharmacopoeia [in Russian], XIIth Ed., Part 1, Moscow (2007), p. 150.Google Scholar
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    OFS 42-0073-07 Radiopharmaceuticals, Russian Federation State Pharmacopoeia [in Russian], XIIth Ed., Part 1, (2007), p. 456.Google Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • D. V. Stepchenkov
    • 1
  • A. A. Semenova
    • 1
  • E. G. Kuz’mina
    • 1
  • A. A. Kuznetsov
    • 2
  • N. M. Rogova
    • 2
  • S. V. Kham’yanov
    • 1
  • N. A. Nerozin
    • 1
  1. 1.A. I. Leipunsky Institute of Physics and Power EngineeringState Scientific Center of the Russian FederationObninskRussia
  2. 2.Medical Radiology Scientific Center, Ministry of Public Health and Social Development of the Russian FederationObninskRussia

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