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Pharmaceutical Chemistry Journal

, Volume 48, Issue 8, pp 543–545 | Cite as

Creating Chitosan-Based Prolonged-Release Film Coatings

  • E. I. Kulish
  • A. S. Shurshina
  • L. G. Kuzina
  • S. V. Kolesov
  • V. P. Zakharov
Article
  • 58 Downloads

The interaction of chitosan with cephalosporin (cefazolin and cefotaxime) and aminoglycoside (amikacin and gentamicin) antibiotics was investigated. It was established that the medicinal preparation could be distributed in the polymer matrix in two ways during formation of the film coating. Apart of it was bound rather strongly to the polymer chain, e.g., via complexation. Another part of it was concentrated in the polymer free space (in polymer pores). Astudy of antibiotic release from chitosan film coatings showed that the release rate from the film was determined on one hand by the amount of antibiotic complexed to chitosan and, on the other, to the condition of the polymer matrix. These films could be suitable for treatment of surgical wounds, burns, and slow-healing wounds of various etiology.

Keywords

medicinal films chitosan antibiotics 

Notes

Acknowledgments

The work was supported financially by the Ministry of Education and Science of the Russian Federation for the “Development of Physicochemical Bases for Creating New Polymeric Medical Materials with Controlled Sorption, Rheological, and Structural Characteristics Based on Natural and Synthetic Polymers.”

References

  1. 1.
    N. A. Plate and A. E. Vasil?ev, Physiologically Active Polymers [in Russian], Khimiya, Moscow (1986).Google Scholar
  2. 2.
    K. G. Skryabin, G. A. Vikhoreva, and V. P. Varlamov, Chitin and Chitosan. Preparation, Properties, and Use [in Russian], Nauka, Moscow (2002).Google Scholar
  3. 3.
    R. Kh. Mudarisova, E. I. Kulish, S. V. Kolesov, and Yu. B. Monakov, Zh. Prikl. Khim., 82(5), 347 – 349 (2009).Google Scholar
  4. 4.
    R. Kh. Mudarisova, E. I. Kulish, N. R. Ershova, et al., Zh. Prikl. Khim., 83(6), 1006 – 1008 (2010).Google Scholar
  5. 5.
    M. D. Mashkovskii, Drugs [in Russian], Vol. 2, Torsing, Kharkov (1997).Google Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • E. I. Kulish
    • 1
  • A. S. Shurshina
    • 1
  • L. G. Kuzina
    • 1
  • S. V. Kolesov
    • 1
  • V. P. Zakharov
    • 1
  1. 1.Bashkir State UniversityUfaRussia

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