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Pharmaceutical Chemistry Journal

, Volume 48, Issue 6, pp 408–413 | Cite as

Analytical Method Development for Tablets of the New Kappa-Opioid Agonist RU-1205

  • A. A. Illarionov
  • L. N. Grushevskaya
  • L. M. Gaevaya
  • M. E. Dudenkova
  • N. I. Avdyunina
  • B. M. Pyatin
  • K. V. Alekseev
  • E. V. Blynskaya
  • I. V. Bogunova
Structure of Chemical Compounds, Methods of Analysis and Process Control

An analytical method for tablets of the new imidazobenzimidazole kappa-opioid agonist RU-1205 was developed. The principal pharmacopoeial parameters of tablet quality were studied. The contents of impurities and RU-1205 in the tablets were assayed quantitatively using HPLC. A method for determining the dose uniformity using UV spectrophotometry was developed. Procedures were proposed for determining the authenticity and dissolution profile of RU-1205 tablets.

Keywords

RU-1205 tablets pharmaceutical analysis analytical method HPLC UV spectrophotometry impurities quantitative determination dose uniformity dissolution test 

References

  1. 1.
    A. A. Spasov, V. A. Anisimova, P. M. Vasil’ev, et al., “Kappa-opioid agonist,” RU Pat. 2,413,512, Mar. 10, 2011; Byull. Izobret., No. 7 (2011).Google Scholar
  2. 2.
    A. A. Illarionov, L. N. Grushevskaya, and L. M. Gaevaya, Khim.-farm. Zh., 48(5), 50 – 56 (2014).Google Scholar
  3. 3.
    USSR State Pharmacopoeia. XIth Ed., Meditsina, Moscow, 1990, p. 154.Google Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • A. A. Illarionov
    • 1
  • L. N. Grushevskaya
    • 1
  • L. M. Gaevaya
    • 1
  • M. E. Dudenkova
    • 1
  • N. I. Avdyunina
    • 1
  • B. M. Pyatin
    • 1
  • K. V. Alekseev
    • 1
  • E. V. Blynskaya
    • 1
  • I. V. Bogunova
    • 1
  1. 1.Zakusov State Institute of Pharmacology, Russian Academy of Medical SciencesMoscowRussia

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