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Sydnone Sulfonamide Derivatives as Antibacterial, Antifungal, Antiproliferative and Anti-HIV Agents

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Pharmaceutical Chemistry Journal Aims and scope

Three series of substituted sydnone sulfonamide derivatives were synthesized wherein 3-(4-methylphenyl)-4-(chlorosulfonyl)sydnone (5) was linked by a sulfonamide linkage with various thiazole, benzothiazole and quinazoline groups. The structures of the compounds were confirmed by IR and NMR spectroscopy and elemental analysis. The synthesized compounds were evaluated for their antibacterial, antifungal, antiproliferative and anti-HIV activities. Anti-HIV activity was determined against human immunodeficiency virus HIV-1 (III-B) and HIV-2 (ROD) in MT-4 cells. Inhibition of cytomegalovirus and varicella-zoster virus (VZV) replication was measured in human embryonic lung (HEL) cells.

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Acknowledgements

One of the authors (STA) thanks the University Grants Commission (New Delhi) for providing a Research Fellowship. He is also thankful to Atul Limited, Valsad and Ami Organics, Sachin for providing some useful chemicals.

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Authors and Affiliations

  1. Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat, 395007, Gujarat, India

    Shahrukh T. Asundaria & Keshav C. Patel

  2. Rega Institute for Medical Research, K. U. Leuven, Leuven, Belgium

    Christophe Pannecouque & Erik De Clercq

Authors
  1. Shahrukh T. Asundaria
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  2. Christophe Pannecouque
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  3. Erik De Clercq
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  4. Keshav C. Patel
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Correspondence to Keshav C. Patel.

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Asundaria, S.T., Pannecouque, C., De Clercq, E. et al. Sydnone Sulfonamide Derivatives as Antibacterial, Antifungal, Antiproliferative and Anti-HIV Agents. Pharm Chem J 48, 260–268 (2014). https://doi.org/10.1007/s11094-014-1090-y

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  • DOI: https://doi.org/10.1007/s11094-014-1090-y

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