Skip to main content
SpringerLink
Log in

Synthesis, Biological Activity, and Mechanism of Action of Mono-Substituted 5-Halouracil Salts

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Mono-substituted sodium salts of 5-fluoro-, 5-chloro-, 5-bromo-, and 5-iodouracil were synthesized. The toxicity and effect of the synthesized compounds on the DNA-binding activity of transcription factors CREB, NFAT, NF-κB, p53, STAT1, GAS, VDR, HSF1, and HIF1á were studied. It was found that the sodium salts of 5-chloro-, 5-bromo-, and 5-iodouracil did not exhibit cytotoxicity comparable with that of the sodium salt of 5-fluorouracil.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. S. Prachayasittikul, N. Sornsongkhram, R. Pingaew, et al., Molecules, 14(8), 2768 – 2779 (2009).

    Article  CAS  PubMed  Google Scholar 

  2. J. L. Grem, Invest. New Drugs, 18(4), 299 – 313 (2000).

    Article  CAS  PubMed  Google Scholar 

  3. U. P. Singh, B. N. Singh, A. K. Ghose, et al., J. Inorg. Biochem., 44(4), 277 – 282 (1991).

    Article  CAS  PubMed  Google Scholar 

  4. Y. Yoshimura, K. Kitano, K. Yamada, et al., Bioorg. Med. Chem., 8(7), 1545 – 1558 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. D. W. Adair, K. A. Smiles, and D. King, Eur. Pat. Appl. EP 0565412 A1, 51, Apr. 2, 1993 (1993).

  6. M. Kh. Salimgareeva, S. V. Sadovnikov, E. I. Farafontova, et al., Prikl. Biokhim. Mikrobiol., 50(2), 1 – 8 (2014).

    Google Scholar 

  7. P. M. Chumakov, Biokhimiya, 65(1), 34 – 47 (2000).

    Google Scholar 

  8. D. B. Longley, D. P. Harkin, and P. G. Johnston, Nat. Rev. Cancer, 3, 330 – 338 (2003).

    Article  CAS  PubMed  Google Scholar 

  9. S. C. Correia and P. I. Moreira, J. Neurochem., 112, 1 – 12 (2010).

    Article  CAS  PubMed  Google Scholar 

  10. R. Ravizza, R. Molteni, and M. Gariboldi, Eur. J. Cancer, 45, 890 – 898 (2009).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences, Ufa, 450054, Bashkortostan, Russia

    M. Kh. Salimgareeva, E. I. Farafontova & Yu. V. Vakhitova

  2. Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, Ufa, 450054, Bashkortostan, Russia

    G. S. Abdrakhimova & S. P. Ivanov

Authors
  1. M. Kh. Salimgareeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. I. Farafontova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. S. Abdrakhimova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. P. Ivanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yu. V. Vakhitova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. P. Ivanov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 4, pp. 14 – 16, April, 2014.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Salimgareeva, M.K., Farafontova, E.I., Abdrakhimova, G.S. et al. Synthesis, Biological Activity, and Mechanism of Action of Mono-Substituted 5-Halouracil Salts. Pharm Chem J 48, 235–237 (2014). https://doi.org/10.1007/s11094-014-1084-9

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-014-1084-9

Keywords

Search

Navigation