Pharmaceutical Chemistry Journal

, Volume 47, Issue 11, pp 593–595 | Cite as

Synthesis and Analgesic Activity of Substituted Pyridoquinoxalinyl Arylates and their Hydrolysis Products

  • N. Yu. Lisovenko
  • Ya. V. Yukova
  • R. R. Makhmudov

Thermolysis of 5-aryl-4-quinoxalin-2-ylfuran-2,3-diones yielded 6-aryl-9-(3-aryl-2-quinoxalinyl)-7-aroyl-10-oxo-10H-pyrido[1,2-a]quinoxalin-8-yl arylates, alkaline hydrolysis of which produced 6-aryl-9-(3-aryl-2-quinoxalinyl)-7-aroyl-8-hydroxy-10H-pyrido[1,2-a]quinoxalin-10-ones. The compounds synthesized here had analgesic activity.


analgesic activity 6-aryl-9-(3-aryl-2-quinoxalinyl)-7-aroyl-10-oxo-10H-pyrido[1,2-a]quinoxalin-8-yl arylates 6-aryl-9-(3-aryl-2-quinoxalinyl)-7-aroyl-8-hydroxy-10H-pyrido[1,2-a]quinoxalin-10-ones 


This study was supported by the Perm Regional Ministry of Education (MIG project) and the Russian Foundation for Basic Research (Grant No. 13 – 03 – 96024-r ural a).


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • N. Yu. Lisovenko
    • 1
  • Ya. V. Yukova
    • 1
  • R. R. Makhmudov
    • 2
    • 3
  1. 1.Perm State National Research UniversityPermRussia
  2. 2.Institute of Natural SciencesPerm National Research UniversityPermRussia
  3. 3.Federal Scientific Center for Medical and Preventive Technologies for Population Health Risk ManagementPermRussia

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