Pharmaceutical Chemistry Journal

, Volume 47, Issue 11, pp 577–580 | Cite as

Effects of Melaxen and Valdoxan on Superoxide Dismutase and Catalase Activities in Experimental Hyperthyroidism

  • M. V. Gorbenko
  • T. N. Popova
  • K. K. Shul’gin
  • S. S. Popov

The effects of Melaxen and Valdoxan on measures of biochemiluminescence (BCL) were studied on the background of the development of experimental hyperthyroidism in terms of the light sum of chemiluminescence (S) and the maximum peak intensity (I max), which characterize the intensity of free radical processes, and the tangent of the kinetic curve slope (tgα2), which reflects total antioxidant activity; effects on superoxide dismutase and catalase activities in tissues and serum were also studied. Increases in these measures due to oxidative stress in experimental hyperthyroidism were found to normalize in response to these agents.


Hyperthyroidism free radical oxidation Melaxen Valdoxan superoxide dismutase catalase 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • M. V. Gorbenko
    • 1
  • T. N. Popova
    • 1
  • K. K. Shul’gin
    • 1
  • S. S. Popov
    • 2
  1. 1.Voronezh State UniversityVoronezhRussia
  2. 2.N. N. Burdenko Voronezh State Medical AcademyVoronezhRussia

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