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Pharmaceutical Chemistry Journal

, Volume 47, Issue 10, pp 536–538 | Cite as

Synthesis and antibacterial activity of 5-aryl-4-acyl-3-hydroxy-1-(2-hydroxyethyl)-3-pyrrolin-2-ones

  • V. L. Gein
  • T. F. Odegova
  • A. N. Korol’
  • L. I. Varkentin
  • A. A. Bobyleva
  • L. F. Gein
  • M. I. Vakhrin
Article

5-Aryl-4-acyl-3-hydroxy-1-(2-hydroxyethyl)-3-pyrrolin-2-ones were synthesized using the reaction of ethanolamine with a mixture of aromatic aldehyde and methyl acylpyruvates. The antibacterial activity of the synthesized compounds was studied.

Keywords

5-aryl-4-acyl-3-hydroxy-1-(2-hydroxyethyl)-3-pyrrolin-2-ones synthesis antibacterial activity 

References

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    M. D. Mashkovskii, Drugs [in Russian], Novaya Volna, Moscow (2010), pp. 116, 214, 556, 616, 788.Google Scholar
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    J. Coleman and K.-G. Rem, Descriptive Biochemistry [Russian translation], Mir, Moscow (2000), p. 409.Google Scholar
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    V. L. Gein, A. A. Bobyleva, E. B. Levandovskaya, et al., Khim.-farm. Zh., 1(46), 26 – 28 (2012).Google Scholar
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    V. L. Gein, Tetrahydropyrrole- and Tetrahydrofuran-2,3-diones [in Russian], PSPA, Perm (2004), p. 84.Google Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • V. L. Gein
    • 1
  • T. F. Odegova
    • 1
  • A. N. Korol’
    • 1
  • L. I. Varkentin
    • 1
  • A. A. Bobyleva
    • 1
  • L. F. Gein
    • 1
  • M. I. Vakhrin
    • 1
  1. 1.Perm State Pharmaceutical AcademyPermRussia

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