New Opportunities for the Synthesis of Quinoxaline-Substituted Heterocyclic and Aryl Moieties
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6.7-Difluoroquinoxaline (I) reacted with dimedone, indandione, and 3-methyl-1-phenylpyrazol-5-one in DMSO solution in the presence of acid to form mono-substituted products IIa – c. Heating I with resorcinol in EtOH in the presence of acid gave resorcinol derivative IId. 6.7-Difluoroquinoxaline in the presence of base reacted with 3-methyl-1-phenylmethylpyrazol-5-one to form dipyrazolylmethane III and tetrapyrazolylethane derivative IV. Heating products IIa – c with N-methylpiperazine produced 7-methylpiperazine derivatives Va – c of 2-substituted quinoxalines.
Keywords6.7-difluoroquinoxaline reactions with nucleophiles
We thank the RFBR (Grant No. 11-03-00579-a) for financial support.
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