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Pharmaceutical Chemistry Journal

, Volume 47, Issue 9, pp 498–502 | Cite as

New Opportunities for the Synthesis of Quinoxaline-Substituted Heterocyclic and Aryl Moieties

  • Yu. A. Azev
  • M. I. Kodess
  • M. A. Ezhikova
  • A. M. Gibor
  • V. I. Baranov
  • O. S. Ermakova
  • V. A. Bakulev
Drug Synthesis Methods and Manufacturing Technology

6.7-Difluoroquinoxaline (I) reacted with dimedone, indandione, and 3-methyl-1-phenylpyrazol-5-one in DMSO solution in the presence of acid to form mono-substituted products IIa – c. Heating I with resorcinol in EtOH in the presence of acid gave resorcinol derivative IId. 6.7-Difluoroquinoxaline in the presence of base reacted with 3-methyl-1-phenylmethylpyrazol-5-one to form dipyrazolylmethane III and tetrapyrazolylethane derivative IV. Heating products IIa – c with N-methylpiperazine produced 7-methylpiperazine derivatives Va – c of 2-substituted quinoxalines.

Keywords

6.7-difluoroquinoxaline reactions with nucleophiles 

Notes

Acknowledgments

We thank the RFBR (Grant No. 11-03-00579-a) for financial support.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Yu. A. Azev
    • 1
  • M. I. Kodess
    • 2
  • M. A. Ezhikova
    • 2
  • A. M. Gibor
    • 1
  • V. I. Baranov
    • 1
  • O. S. Ermakova
    • 1
  • V. A. Bakulev
    • 1
  1. 1.Department of ChemistryUral Federal UniversityYekaterinburgRussia
  2. 2.Postovsky Institute of Organic Synthesis, Ural BranchRussian Academy of SciencesYekaterinburgRussia

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