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Pharmaceutical Chemistry Journal

, Volume 47, Issue 8, pp 442–445 | Cite as

Effects of Dissolution Medium Composition on Ropinirole Release from Slow-Release Solid Dosed Formulations

  • T. A. Yarushok
  • I. E. Shokhin
  • Yu. V. Medvedev
Article
  • 61 Downloads

Comparative dissolution kinetics were studied for ropinirole formulations using two media with pH 4.0: phosphate buffered solution (200 rpm) and citrate buffer (100 rpm). The study results showed that the components of the dissolution medium affected release profiles and the stability of the active ingredient even at identical pH. The optimum dissolution medium was citrate buffer solution, which provided the best release of active ingredient, with retention of the structure of the active substance.

Keywords

“dissolution” test dissolution medium ropinirole 

References

  1. 1.
    K. Gowthamarajan and Sachin Kumar Singh, Dissol. Technol., 17(3), 24–32 (2010).Google Scholar
  2. 2.
    P. A. Dickinson, W. W. Lee, P. W. Stott, et al., Am. Ass. Pharm. Sci. J., 10(2), 380–390.Google Scholar
  3. 3.
    S. A. Qureshi, Dissol. Technol., November, 18–23 (2006).Google Scholar
  4. 4.
    S. S. D’Souza, R. Lozano, S. Mayock, and V. Gray, Dissol. Technol., November, 41–34, (2010).Google Scholar
  5. 5.
    State Medicine Standard [in Russian], General Pharmacopeia Monograph 42 – 0003 – 04 “Dissolution” (2004).Google Scholar
  6. 6.
    K. S. Davydova, Yu. I. Kulinich, I. W. Shokhin, Remedium, No. 5, 42 (2010).Google Scholar
  7. 7.
    E. A. Volkova, I. E. Shokhin, G. V. Ramenskaya, et al., Biomeditsina, No. 3, 133–140 (2011).Google Scholar
  8. 8.
    ”FIP guidelines for dissolution testing of solid oral products. Joint report of the Section for Official Laboratories and Medicines Control Services and the Section of Industrial Pharmacists of the FIP,” Pharm Ind., 57(5), 362–369 (1995).Google Scholar
  9. 9.
    R. Brickl, Am. Pharm. Rev., No. 1, 98–102 (2010).Google Scholar
  10. 10.
    Dissolution for Solid Dosed Medicines [in Russian], General Pharmacopeia Monograph OFS-42-0135-09, State Pharmacopeia, (2010), XII edition, Part 2.Google Scholar
  11. 11.
    FDA Database: Ropinirole Official FDA http://www.drugs.com/pro/ripinirole.html. Viewed on 30.05.2013.
  12. 12.
    Methodological Guidelines: “Assessment of the Bioequivalence of Medicines [in Russian], Russian Federation Ministry of Health and Social Development, Moscow (2008).Google Scholar
  13. 13.
    Methodological Guidelines on in Vitro Assessment of Equivalence of Generic Medicines Using the “Biowaiver” Procedure for Drug Developers and Manufacturers [in Russian], Moscow (2010).Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • T. A. Yarushok
    • 1
  • I. E. Shokhin
    • 1
  • Yu. V. Medvedev
    • 1
  1. 1.I. M. Sechenov First Moscow State Medical University, Russian Ministry of HealthMoscowRussia

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