Pharmaceutical Chemistry Journal

, Volume 47, Issue 8, pp 442–445 | Cite as

Effects of Dissolution Medium Composition on Ropinirole Release from Slow-Release Solid Dosed Formulations

  • T. A. Yarushok
  • I. E. Shokhin
  • Yu. V. Medvedev

Comparative dissolution kinetics were studied for ropinirole formulations using two media with pH 4.0: phosphate buffered solution (200 rpm) and citrate buffer (100 rpm). The study results showed that the components of the dissolution medium affected release profiles and the stability of the active ingredient even at identical pH. The optimum dissolution medium was citrate buffer solution, which provided the best release of active ingredient, with retention of the structure of the active substance.


“dissolution” test dissolution medium ropinirole 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • T. A. Yarushok
    • 1
  • I. E. Shokhin
    • 1
  • Yu. V. Medvedev
    • 1
  1. 1.I. M. Sechenov First Moscow State Medical University, Russian Ministry of HealthMoscowRussia

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