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Pharmaceutical Chemistry Journal

, Volume 47, Issue 7, pp 361–365 | Cite as

Synthesis and Biological Activity of N-[3-(4-Substituted Phenyl)-3-hydroxypropyl]valines and -Tryptophans, and 3-{[3-Hydroxy-3-(4-substituted phenyl)propyl]amino}-3-phenylpropanoic Acids

  • A. G. Agababyan
  • G. A. Gevorgyan
  • A. P. Avakyan
  • A. E. Tumadzhyan
  • R. G. Paronikyan
  • G. A. Panosyan
Article

Reduction of N-[β-(4-substituted benzoyl)ethyl]amino acids with sodium borohydride yielded arylaliphatic aminopropanols containing amino acid fragments – N-[3-(4-substituted phenyl)-3-hydroxypropyl]valines,-tryptophans, and 3-{[3-hydroxy-3-(4-substituted phenyl)propyl]amino}-3-phenylpropanoic acids. Studies of the biological activities of these compounds showed that some had anti-inflammatory and anticonvulsive activities.

Keywords

N-[β-(4-substituted benzoyl)ethyl]amino acids synthesis reduction with NaBH4 N-[3-(4-substituted phenyl)-3-hydroxypropyl]amino acids 3-{[3-hydroxy-3-(4-substituted phenyl)propyl]amino}-3-phenylpropanoic acids anti-inflammatory and anticonvulsive activities 

References

  1. 1.
    A. G. Agababyan, G. A. Gevorgyan, A. E. Tumadzhyan, et al., Khim.-Farm. Zh., 43(1), 14 – 16 (2009).Google Scholar
  2. 2.
    M. G. Malakyan, L. A. Vardevanyan, L. A. Egiazaryan, et al., Khim.-Farm. Zh.., 44(8), 19 – 22 (2010).Google Scholar
  3. 3.
    A. G. Agababyan, G. A. Gevorgyan, R. G. Paronikyan, et al., Khim. Zh. Armenii, 62(1 – 2), 170 – 175 (2009).Google Scholar
  4. 4.
    A. G. Agababyan, G. A. Gevorgyan., L. M. Mkrtchyan, Khim. Zh. Armenii, 56(1 – 2), 72 – 77 (2003).Google Scholar
  5. 5.
    Guidelines for Experimental (Preclinical) Studies of New Pharmacological Substances [in Russian], R. U. Khabriev (ed.), Meditsina, Moscow (2005).Google Scholar
  6. 6.
    H. G. Vogel, in: Drug Discovery and Evaluation: Pharmacological Assays, H. G. Vogel (ed.), Berlin, New York (2008), pp. 569 – 874.Google Scholar
  7. 7.
    R. D. Sofia, J. Pharm. Sci., 58, 900 – 901 (1969).PubMedCrossRefGoogle Scholar
  8. 8.
    M. D. Mashkovskii, Drugs [in Russian], Novaya Volna, Moscow (2007).Google Scholar
  9. 9.
    J. T. Litchfield, F. A. Wilcoxon, J. Pharm. Exp. Ther., 96, 99 – 113 (1949).Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • A. G. Agababyan
    • 1
  • G. A. Gevorgyan
    • 1
  • A. P. Avakyan
    • 1
  • A. E. Tumadzhyan
    • 1
  • R. G. Paronikyan
    • 1
  • G. A. Panosyan
    • 2
  1. 1.Organic and Pharmaceutical Chemistry Science and Technology Center, National Academy of Sciences of the Republic of Armenia, A. L. Mndzhoyan Institute of Fine Organic ChemistryErevanArmenia
  2. 2.Molecular Structure Study CenterNational Academy of Sciences of the Republic of ArmeniaYerevanArmenia

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