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Pharmaceutical Chemistry Journal

, Volume 47, Issue 5, pp 239–242 | Cite as

Synthesis and Anxiosedative and Antidepressant Properties of α-[4-Oxoquinazolin-3(4H)-yl]carboxylic Acid Anilides

  • I. N. Tyurenkov
  • A. A. Ozerov
  • E. A. Solodunova
  • Yu. V. Archakova
  • E. N. Shmatova
  • K. T. Sampieva
Search for New Drugs

A series of new quinazoline acetanilide derivatives were synthesized by direct alkylation of quinazoline-4(3H)-one with α-chlorocarboxylic acid anilides. The anxiosedative and antidepressant properties of 10 original derivatives of α-[4-oxoquinazolin-3(4H)-yl]carboxylic acids were studied. It was established that N-(4-methoxyphenyl)-2-[4-oxo-3(4H)-quinazoline]acetamide and 3-[2-oxo-2-(4-phenyl-1-piperazinyl)-ethyl]quinazoline-4(3H)-one exhibited pronounced anxiolytic, antiphobic, and antidepressant activity and were promising candidates for further studies of their psychotropic properties.

Keywords

quinazoline derivatives anxiolytic and antidepressant activity 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • I. N. Tyurenkov
    • 1
  • A. A. Ozerov
    • 1
  • E. A. Solodunova
    • 1
  • Yu. V. Archakova
    • 1
  • E. N. Shmatova
    • 1
  • K. T. Sampieva
    • 1
  1. 1.Volgograd State Medical UniversityVolgogradRussia

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