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Pharmaceutical Chemistry Journal

, Volume 46, Issue 11, pp 647–652 | Cite as

Synthesis and pharmacological activity of amides of 2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazolyln-acetic acids

  • V. A. Anisimova
  • A. A. Spasov
  • V. A. Kosolapov
  • I. E. Tolpygin
  • E. V. Tibir’kova
  • O. A. Salaznikova
  • V. A. Kuznetsova
  • N. A. Gurova
  • K. V. Lenskaya
  • D. S. Yakovlev
  • D. V. Mal’tsev
  • N. A. Kolobrodova
  • T. M. Mitina
  • O. Yu. Grechko
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A series of amides of 2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazolyl-N-acetic acids were synthesized. Their pharmacological activity was studied. It was established that the synthesized substances possessed antiaggregant properties and antiarrhythmic activity. Some of these amides exhibited antioxidant and hypoglycemic effects in addition to antagonist activity with respect to serotonin 5-HT2 and purine P2Y1 receptors.

Keywords

synthesis acetamides 2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1,2a]benzimidazoles antiaggregant properties antiarrhythmic activity P2Y1- and 5-HT2-antagonist activity hypoglycemic properties antioxidant action 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • V. A. Anisimova
    • 1
  • A. A. Spasov
    • 2
    • 3
    • 4
  • V. A. Kosolapov
    • 2
    • 3
  • I. E. Tolpygin
    • 2
  • E. V. Tibir’kova
    • 3
  • O. A. Salaznikova
    • 2
  • V. A. Kuznetsova
    • 3
  • N. A. Gurova
    • 2
  • K. V. Lenskaya
    • 2
  • D. S. Yakovlev
    • 2
    • 4
  • D. V. Mal’tsev
    • 2
  • N. A. Kolobrodova
    • 4
  • T. M. Mitina
    • 2
  • O. Yu. Grechko
    • 2
  1. 1.Research Institute of Physical and Organic ChemistrySouth Federal UniversityRostov-on-DonRussia
  2. 2.Volgograd State Medical UniversityVolgogradRussia
  3. 3.Research Institute of PharmacologyVolgograd State Medical UniversityVolgogradRussia
  4. 4.Volgograd Scientific CenterRussian Academy of Medical SciencesVolgogradRussia

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