Pharmaceutical Chemistry Journal

, Volume 46, Issue 9, pp 553–564 | Cite as

Structure–activity relationship in a series of natural and synthetic inhibitors of 5-lipoxygenase catalytic activity

  • V. R. Khairullina
  • I. A. Taipov
  • A. Ya. Gerchikov
  • F. S. Zarudii

Structural features characteristic of high-, medium-, and low-efficiency inhibitors of 5-lipoxygenase (5-LOG) catalytic activity were established. The degree of their influence on the inhibition efficiency was assessed. Two models (M1 and M2) were constructed for the prediction and recognition of the efficiency intervals of 5-LOG inhibitors. The confidence level of activity prediction for M1 and M2 reached 90 and 70%, respectively. The revealed structural features could be used for constructing highly selective inhibitors of 5-LOG catalytic activity.

Key words

5-lipoxygenase structure—activity relationship inhibitors of catalytic activity 


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • V. R. Khairullina
    • 1
  • I. A. Taipov
    • 1
  • A. Ya. Gerchikov
    • 1
  • F. S. Zarudii
    • 2
  1. 1.Bashkir State UniversityUfaRussia
  2. 2.Bashkir State Medical UniversityUfaRussia

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