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Pharmaceutical Chemistry Journal

, Volume 46, Issue 8, pp 492–494 | Cite as

Anxiolytic activity of biologically active compounds from Filipendula vulgaris

  • V. V. Udut
  • A. I. Vengerovskii
  • N. I. Suslov
  • I. V. Shilova
  • A. V. Kaigorodtsev
  • N. Yu. Polomeeva
  • A. M. Dygai
Article

The composition of biologically active compounds in Filipendula vulgaris aqueous extract and its EtOAc and BuOH fractions was studied. The total extract and its fractions contained phenols, coumarins, triterpenes, carbohydrates, and amino acids. The influence of the aqueous extract of F. vulgaris and its fractions on the behavior of mice in the elevated plus-maze and open-field tests was studied. It was established that the EtOAc fraction had the most pronounced anxiolytic effect.

Key words

Filipendula vulgaris aqueous extract biologically active compounds anxiolytic action anxiety models 

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • V. V. Udut
    • 1
  • A. I. Vengerovskii
    • 2
  • N. I. Suslov
    • 1
  • I. V. Shilova
    • 1
  • A. V. Kaigorodtsev
    • 2
  • N. Yu. Polomeeva
    • 1
  • A. M. Dygai
    • 1
  1. 1.Institute of Pharmacology, Siberian BranchRussian Academy of Medical SciencesTomskRussia
  2. 2.Siberian State Medical UniversityTomskRussia

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