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Pharmaceutical Chemistry Journal

, Volume 46, Issue 6, pp 372–375 | Cite as

Chemical composition and pharmacological activity of Ruscus colchicus leaves

  • E. P. Kemertelidze
  • T. S. Muzashvili
  • M. M. Benidze
  • A. V. Tsaruk
  • Z. A. Khushbaktova
  • V. N. Syrov
Article

Phylloclades of Ruscus colchicus P. F. Yeo turned out to be a rich source of steroidal glycosides with the biosynthesis of up to 40 steroids. A total of 22 pure compounds were isolated and identified including 1 cholestanol, 17 furostanol, and 4 spirostanol glycosides, among which 16 appeared to be novel organic compounds. Attention was drawn to the high number of sulfated compounds including six furostanols, two spirostanols, and one cholestanol. A pharmacological investigation showed that an aqueous EtOH extract of R. colchicus leaves exhibited pronounced lactogenic action.

Key words

steroidal glycosides Ruscus colchicus lactogenic action 

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • E. P. Kemertelidze
    • 1
  • T. S. Muzashvili
    • 1
  • M. M. Benidze
    • 1
  • A. V. Tsaruk
    • 2
  • Z. A. Khushbaktova
    • 1
  • V. N. Syrov
    • 2
  1. 1.TbilisiRepublic of Georgia
  2. 2.TashkentUzbekistan

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