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Pharmaceutical Chemistry Journal

, Volume 46, Issue 6, pp 325–330 | Cite as

Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles

  • V. A. Anisimova
  • I. E. Tolpygin
  • A. A. Spasov
  • D. S. Yakovlev
  • N. A. Kolobrodova
  • N. A. Gurova
  • O. A. Salaznikova
  • L. V. Naumenko
  • V. A. Kosolapov
  • L. V. El’tsova
  • T. M. Mitina
  • M. P. Voronkova
  • K. V. Lenskaya
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The synthesis of 10-chloroethyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazole was described. The nucleophilic substitution of the chlorine atom by various amines was studied. As a result, 10-alkylaminoethyl-substituted derivatives of this tricycle containing alkylamines and 4-substituted piperazines were obtained. These compounds exhibited 5-HT2 antagonist activity; platelet antiaggregant properties; and moderate P2Y1-antagonist, antiarrhythmic, and hypoglycemic action.

Keywords

synthesis 2,3,4-10-tetrahydropyrimido[1,2-a]benzimidazole antiaggregant activity antiarrhythmic action 5-HT2 antagonist activity hypoglycemic properties P2Y1-antagonist action 

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • V. A. Anisimova
    • 1
  • I. E. Tolpygin
    • 1
  • A. A. Spasov
    • 2
    • 3
    • 4
  • D. S. Yakovlev
    • 2
    • 4
  • N. A. Kolobrodova
    • 4
  • N. A. Gurova
    • 2
  • O. A. Salaznikova
    • 2
  • L. V. Naumenko
    • 2
  • V. A. Kosolapov
    • 2
    • 3
  • L. V. El’tsova
    • 2
    • 3
  • T. M. Mitina
    • 2
  • M. P. Voronkova
    • 2
  • K. V. Lenskaya
    • 2
  1. 1.Research Institute of Physical and Organic ChemistrySouthern Federal UniversityRostov-on-DonRussia
  2. 2.Volgograd State Medical UniversityVolgogradRussia
  3. 3.Research Institute of PharmacologyVolgograd State Medical UniversityVolgogradRussia
  4. 4.Volgograd Scientific CenterRussian Academy of Medical SciencesVolgogradRussia

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