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Pharmaceutical Chemistry Journal

, Volume 45, Issue 11, pp 655–659 | Cite as

Synthesis and antiviral activity of 1,2,4-triazine derivatives

  • V. L. Rusinov
  • I. N. Egorov
  • O. N. Chupakhin
  • E. F. Belanov
  • N. I. Bormotov
  • O. A. Serova
The Search for New Drugs

Interaction of 3-aryl-1,2,4-triazin-5(4H)-ones with indole and its methyl derivative in the presence of N-substituted amino acids activated with dicyclohexylcarbodiimide or ethyl chloroformate led to the formation of 1-acyl-6-indolyl-3-phenyl-1,6-dihydro-1,2,4-triazin-5(4H)-ones. The cytotoxic and antiviral actions of the 12 resulting compounds were studied using vaccinia virus.

Key words

1,2,4-Triazines indoles naproxen antiviral activity amino acids 

Notes

This study was supported by the Analytic Departmental Targeted Program “Development of Scientific Potential of Higher Schools” Program, regulation No. 2.1.1/5811, and State Control No. 02.512.11.2237.

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • V. L. Rusinov
    • 1
    • 2
  • I. N. Egorov
    • 1
  • O. N. Chupakhin
    • 1
    • 2
  • E. F. Belanov
    • 3
  • N. I. Bormotov
    • 3
  • O. A. Serova
    • 3
  1. 1.B. N. El’tsin Urals State Technical UniversityEkaterinburgRussia
  2. 2.I. Ya. Postovskii Institute of Organic Synthesis, Urals Branch, Russian Academy of SciencesEkaterinburgRussia
  3. 3.State Scientific Center for Virology and Biotechnology “Vektor”Novosibirsk RegionRussia

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