GB-115 is an original peptide anxiolytic with the structure N-(6-phenylhexanoyl)glycyl-L-tryptophan amide that has been developed at Zakusov State Institute of Pharmacology (Moscow). The physicochemical properties of GB-115 parent substance were studied. Analytical procedures for it were elaborated. General pharmacopoeial quality characteristics have been determined. UV, IR, and NMR spectra have been measured. A method for determining foreign impurities in GB-115 parent substance that is based on HPLC was developed.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 10, pp. 53 – 56, October, 2011.
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Klumova, V.S., Grushevskaya, L.N., Avdyunina, N.I. et al. Physicochemical properties of and analytical method for the original anxiolytic substance GB-115. Pharm Chem J 45, 646–649 (2012). https://doi.org/10.1007/s11094-012-0695-2
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DOI: https://doi.org/10.1007/s11094-012-0695-2