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Pharmaceutical Chemistry Journal

, Volume 45, Issue 10, pp 646–649 | Cite as

Physicochemical properties of and analytical method for the original anxiolytic substance GB-115

  • V. S. Klumova
  • L. N. Grushevskaya
  • N. I. Avdyunina
  • B. M. Pyatin
  • M. S. Sergeeva
  • L. M. Gaevaya
  • M. E. Dudenkova
Article
  • 36 Downloads

GB-115 is an original peptide anxiolytic with the structure N-(6-phenylhexanoyl)glycyl-L-tryptophan amide that has been developed at Zakusov State Institute of Pharmacology (Moscow). The physicochemical properties of GB-115 parent substance were studied. Analytical procedures for it were elaborated. General pharmacopoeial quality characteristics have been determined. UV, IR, and NMR spectra have been measured. A method for determining foreign impurities in GB-115 parent substance that is based on HPLC was developed.

Key words

GB-115 anxiolytic pharmaceutical analysis HPLC IR spectroscopy UV spectroscopy 

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • V. S. Klumova
    • 1
  • L. N. Grushevskaya
    • 1
  • N. I. Avdyunina
    • 1
  • B. M. Pyatin
    • 1
  • M. S. Sergeeva
    • 1
  • L. M. Gaevaya
    • 1
  • M. E. Dudenkova
    • 1
  1. 1.Zakusov State Institute of PharmacologyRussian Academy of Medical SciencesMoscowRussia

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