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Pharmaceutical Chemistry Journal

, Volume 45, Issue 8, pp 474–475 | Cite as

Synthesis and antimicrobial activity of 2,6-dimethyl-3,5-dialkoxycarbonyl-4-phenyl- 1,4-dihydropyridines

  • V. L. Gein
  • M. I. Kazantseva
  • A. A. Kurbatova
  • E. V. Voronina
Article

Reaction of acetoacetic esters, aromatic aldehydes, and ammonia formed under Hantzsch conditions 2,6-dimethyl-3,5-dialkoxycarbonyl-1,4-dihydropyridines. The structures of the products were established using mass, IR, and PMR spectra. It was found that all synthesized compounds exhibited moderate antimicrobial activity.

Key words

Hantzsch synthesis 2,6-dimethyl-3,5-dialkoxycarbonyl-4-phenyl-1,4-dihydropyridines antimicrobial activity 

References

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    M. D. Mashkovskii, Drugs [in Russian], Novaya Volna, Moscow (2005).Google Scholar
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    D. P. Khrustalev, A. A. Suleimenova, S. D. Fazylov, et al., Zh. Org. Khim., No. 2, 349 – 350 (2010).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • V. L. Gein
    • 1
  • M. I. Kazantseva
    • 1
  • A. A. Kurbatova
    • 1
  • E. V. Voronina
    • 1
  1. 1.Perm State Pharmaceutical AcademyPermRussia

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